gene

STIM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STIM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

STIM2 - Stromal Interaction Molecule 2 - ER calcium sensor for basal calcium homeostasis

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🧬 Gene Info

Gene Symbol	STIM2
Full Name	Stromal Interaction Molecule 2
Chromosome	4p16.3
Primary Expression	Brain (highest), Immune cells, Endothelial cells
Subcellular Localization	and regulatory properties. The gene promoter contains binding sites for neuronal activity-dependent transcription factor
Molecular Weight	92 kDa
Amino Acids	831 aa
UniProt ID	Q9UQC2
NCBI Gene ID	57679
Ensembl ID	ENSG00000120156
OMIM	605855
GeneCards	STIM2
Human Protein Atlas	STIM2
Brain	Highest expression in hippocampus, cortex, and cerebellum
Neurons	Predominantly neuronal expression (versus STIM1 in glia)
Associated Diseases	Alzheimer's Disease, Parkinson's Disease, Cognitive impairment
Databases	GeneCards HPA STRING

🔮 Predicted Structure: STIM2 — AlphaFold Q9UQC2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

STIM2 Gene

gene · 1199 words

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Pathway Diagram

graph TD
    STIM2["STIM2"]
    neurodegeneration["neurodegeneration"]
    STIM2 -->|"implicated_in"| neurodegeneration
    style STIM2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning STIM2 in their description or question text

No additional research found