concept

COGNITIVE IMPAIRMENT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COGNITIVE IMPAIRMENT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

371Connections

0Hypotheses

1Analyses

30Outgoing

50Incoming

0Experiments

1Debates

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Pathway Diagram

graph TD
    COGNITIVE_IMPAIRMENT["COGNITIVE IMPAIRMENT"]
    Trilobatin["Trilobatin"] -->|"treats"| COGNITIVE_IMPAIRMENT
    Tmt["Tmt"] -->|"causes"| COGNITIVE_IMPAIRMENT
    Ckd["Ckd"] -->|"causes"| COGNITIVE_IMPAIRMENT
    Kidney_Failure["Kidney Failure"] -->|"causes"| COGNITIVE_IMPAIRMENT
    Alzheimer_s_Disease["Alzheimer's Disease"] -->|"causes"| COGNITIVE_IMPAIRMENT
    Rehmannioside_A["Rehmannioside A"] -->|"treats"| COGNITIVE_IMPAIRMENT
    Protective_Genetic_Variants["Protective Genetic Variants"] -->|"modulates"| COGNITIVE_IMPAIRMENT
    Metformin["Metformin"] -.protects against.-> COGNITIVE_IMPAIRMENT
    Neuroinflammation["Neuroinflammation"] -->|"causes"| COGNITIVE_IMPAIRMENT
    MNPs_FMN["MNPs@FMN"] -->|"treats"| COGNITIVE_IMPAIRMENT

Outgoing (30)

Target	Relation	Type	Str
Alzheimer's Disease	associated_with	disease	0.95
Alzheimer's Disease	biomarker_for	disease	0.90
Narcolepsy Type 1	associated_with	disease	0.90
Diabetic Encephalopathy	associated_with	disease	0.85
Alzheimer Disease	associated_with	disease	0.85
PI3K/AKT PATHWAY	activates	concept	0.50
ENDOTHELIAL CELLS	inhibits	concept	0.50
PI3K/AKT SIGNALING	activates	concept	0.50
EXCITOTOXICITY	activates	concept	0.50
Neuroprotection	activates	process	0.50
Gut Microbiota	inhibits	process	0.50
CEREBROSPINAL FLUID	activates	concept	0.50
AMYLOID-β	activates	concept	0.50
Cellular Senescence	inhibits	cell_type	0.50
AMYLOID-β	inhibits	concept	0.50
CEREBROSPINAL FLUID	inhibits	concept	0.50
CX43	inhibits	concept	0.50
PREFRONTAL CORTEX	inhibits	concept	0.50
GENE EXPRESSION	inhibits	concept	0.50
NUCLEUS	inhibits	concept	0.50
Cognitive Decline	inhibits	disease	0.50
NEUTROPHIL	inhibits	cell_type	0.50
NEUTROPHILS	inhibits	concept	0.50
MICROGLIAL ACTIVATION	activates	concept	0.50
Gut Microbiota	activates	process	0.50
CHOLESTEROL METABOLISM	inhibits	concept	0.50
MAPK SIGNALING	inhibits	concept	0.50
Proteins	inhibits	protein	0.50
WNT SIGNALING	inhibits	concept	0.50
CEREBRAL CORTEX	inhibits	concept	0.50

Incoming (341)

Source	Relation	Type	Str
Copper	causes	compound	0.95
ALZHEIMER'S DISEASE	causes	disease	0.95
Ginsenoside Re	treats	compound	0.95
Stem Cell Therapy	treats	drug	0.95
Pterostilbene	treats	compound	0.95
Scopolamine	causes	drug	0.95
p-tau217	correlates_with	biomarker	0.95
Tmt	causes	compound	0.95
Alzheimer's Disease	causes	disease	0.95
Kidney Failure	causes	disease	0.95
Metformin	treats	drug	0.95
Ckd	causes	disease	0.95
Ginsenoside Rk1	treats	compound	0.95
Ginsenoside Ro	treats	compound	0.95
Trilobatin	treats	compound	0.95
Quinolinic Acid	causes	compound	0.95
Butyrate	treats	compound	0.95
Danggui-Shaoyao-San	treats	drug	0.95
Parkinson's Disease	causes	disease	0.95
BDNF	associated_with	protein	0.95
Chronic Kidney Disease	causes	disease	0.95
Parkinson Disease	causes	disease	0.92
Neuroinflammation	causes	process	0.90
MNPs@FMN	treats	drug	0.90
C3A	correlates_with	protein	0.90
Gut-Brain Axis	regulates	pathway	0.90
Neutrophil-Microglia Interactions	mediates	process	0.90
Rehmannioside A	treats	drug	0.90
Protective Genetic Variants	modulates	biomarker	0.90
TDP43	contributes_to	entity	0.90
Protective Genetic Variants	protects_against	biomarker	0.90
APP/PS1	causes	gene	0.90
Aging	associated_with	process	0.90
Exendin-4	treats	drug	0.90
Tanshinone Iia	protects_against	compound	0.90
Tdp-43 Pathology	associated_with	biomarker	0.90
Metformin	protects_against	drug	0.90
SYN1	associated_with	protein	0.90
Prefrontal Cortex	associated_with	brain_region	0.90
Glp1 Receptor Agonists	treats	drug	0.90
P-Tau217	correlates_with	biomarker	0.90
APOE ε4	causes	gene	0.90
AQP4	causes	protein	0.90
TREM2	contributes_to	gene	0.90
Gut-Brain Axis	modulates	pathway	0.90
LARS2	associated_with	gene	0.90
Sulfatide Deficiency	causes	phenotype	0.90
Plasma GFAP	correlates_with	biomarker	0.90
Chronic REM sleep deprivation	causes	process	0.90
Millimeter waves	treats	compound	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Which cell types show the most significant expression changes for neurodegenerat

neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.682

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate mentioned gene expression profiling but did not specify which neural

closed · Rounds: 4 · Score: 0.93 · 2026-04-03