gene

STX10

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about STX10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

STX10 encodes a SNARE protein involved in Golgi trafficking, membrane fusion, and intracellular transport. It plays roles in synaptic vesicle dynamics, autophagy, and is implicated in Alzheimer's disease through effects on amyloid processing and neuronal viability.

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🧬 Gene Info

Gene Symbol	STX10
Full Name	Syntaxin 10
Chromosome	17p13.1
Function	is a tail-anchored protein localized primarily to the Golgi apparatus, where it participates in intracellular trafficking pathways that are critical for proper protein sorting, processing, and secr...
Subcellular Localization	the Golgi apparatus where it mediates membrane fusion events essential for protein trafficking and secretion. The protei
Amino Acids	60 aa
UniProt ID	[Q9Y258](https://www.uniprot.org/uniprot/Q9Y258)
Ensembl ID	ENSG00000169933
GeneCards	STX10
Human Protein Atlas	STX10
N-terminal regulatory domain	Consists of three α-helices that can fold back onto the SNARE motif, regulating SNARE complex formation (open/closed conformation)
SNARE motif	Central region of approximately 60 amino acids containing multiple heptad repeats that form the core of the SNARE complex
Transmembrane anchor	C-terminal membrane-spanning domain that anchors the protein to the Golgi membrane
Length	Approximately 215 amino acids
Phosphorylation	Regulatory phosphorylation affects SNARE complex assembly
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

STX10 — Syntaxin 10

gene · 1538 words

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Pathway Diagram

graph TD
    STX10["STX10"]
    neurodegeneration["neurodegeneration"]
    STX10 -->|"implicated in"| neurodegeneration
    Alzheimer_S_Disease{"Alzheimer'S Disease"}
    STX10 -->|"implicated in"| Alzheimer_S_Disease
    Autophagy(["Autophagy"])
    STX10 -->|"regulates"| Autophagy
    Synaptic_Vesicle(["Synaptic Vesicle"])
    STX10 -->|"regulates"| Synaptic_Vesicle
    AMYLOID["AMYLOID"]
    STX10 ---|"interacts"| AMYLOID
    style STX10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Alzheimer_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Synaptic_Vesicle fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
    style Autophagy fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning STX10 in their description or question text

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