Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STX1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | STX1B |
| Full Name | Syntaxin-1B |
| Chromosome | 16p11.2 |
| Function | The STX1B gene encodes the Syntaxin-1B, a protein involved in synaptic function, axonal transport, and neuronal signaling. |
| Primary Expression | various brain reg |
| Amino Acids | 288 aa |
| UniProt ID | P61264 |
| NCBI Gene ID | 11275 |
| Ensembl ID | ENSG00000199330 |
| OMIM | 616715 |
| GeneCards | STX1B |
| Human Protein Atlas | STX1B |
| N-terminal Domain (Habc domain) | This regulatory domain folds back onto the SNARE motif in an autoinhibitory conformation, regulating the protein's availability for SNARE complex formation[@rizo2018]. |
| SNARE Motif | A central coiled-coil domain of approximately 60 residues that participates in the formation of the ternary SNARE complex with SNAP-25 and VAMP2[@sutton2018]. |
| Transmembrane Anchor | A C-terminal transmembrane domain that anchors Syntaxin-1B to the presynaptic plasma membrane[@galli2016]. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
STX1B["STX1B"]
neurodegeneration["neurodegeneration"]
STX1B -->|"implicated_in"| neurodegeneration
style STX1B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning STX1B in their description or question text
No additional research found