protein

SV2BPROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SV2BPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Synaptic Vesicle Glycoprotein 2B (SV2B) is an integral membrane protein localized to synaptic vesicles that plays essential roles in neurotransmitter release and synaptic function.

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🔬 Protein Info

Gene Symbol	SV2BPROTEIN
Full Name	Synaptic Vesicle Glycoprotein 2B
Protein Type	Protein
Function	is an integral membrane protein localized to synaptic vesicles that plays essential roles in neurotransmitter release and synaptic function.
Primary Expression	the central nervous system, with particular abundance in the hippocampus, cortex, and cerebellum—regions critically affected
Subcellular Localization	to synaptic vesicles that plays essential roles in neurotransmitter release and
UniProt ID	Search UniProt
GeneCards	SV2BPROTEIN
Human Protein Atlas	SV2BPROTEIN
12 transmembrane helices	Arranged in the characteristic MFS fold, forming a putative transport channel
Large luminal loop	Contains multiple glycosylation sites and the binding site for botulinum neurotoxins
Cytoplasmic termini	Short N- and C-terminal domains facing the cytoplasm
Conserved regions	Cysteine residues and sequence motifs shared across the SV2 family
Release probability	SV2B influences the probability of vesicle fusion
Release kinetics	Modulates the timing and dynamics of neurotransmitter release
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SV2BPROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Synaptic Vesicle Glycoprotein 2B Protein

protein · 1644 words

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Pathway Diagram

graph TD
    SV2BPROTEIN["SV2BPROTEIN"]
    neurodegeneration["neurodegeneration"]
    SV2BPROTEIN -->|"implicated_in"| neurodegeneration
    style SV2BPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

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Debates (0)

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Related Research

Hypotheses and analyses mentioning SV2BPROTEIN in their description or question text

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