protein

SYNDECAN3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNDECAN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Syndecan-3 Protein (SDC3)

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🔬 Protein Info

Gene Symbol	SYNDECAN3
Function	In the healthy brain, Syndecan-3 has several important functions
Primary Expression	hypothalamus, regulates energy homeostasis 5
Molecular Weight	~44 kDa (core)
UniProt ID	[Q99971](https://www.uniprot.org/uniprotkb/Q99971)
GeneCards	SYNDECAN3
Human Protein Atlas	SYNDECAN3
Ectodomain	Contains heparan sulfate (HS) and chondroitin sulfate (CS) glycosaminoglycan (GAG) attachment sites
Transmembrane domain	Single-pass membrane anchor highly conserved among syndecans
Cytoplasmic domain	Contains variable (V) region, conserved (C1 and C2) regions, and binds intracellular signaling proteins
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SYNDECAN3["SYNDECAN3"]
    neurodegeneration["neurodegeneration"]
    SYNDECAN3 -->|"implicated_in"| neurodegeneration
    style SYNDECAN3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
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Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found