Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Sirtuin-1 / NAD+ metabolism / deacetylation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| SIRT1 | participates_in | gene | 0.62 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Nutrient-Sensing Epigenetic Circuit Reactivation | 0.670 | neurodegeneration | Epigenetic reprogramming in aging neuron |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.670
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| NAD+ subcellular partitioning mediated by miR-183 and miR-96 regulates muscle st [PMID:41915008] | Ma M, Ma R, Li Z, Shen S, Kong W, Qiu T, | Journal of molecular cell biol | 2026 | 0 |
| Rhodiola sacra Protects Against Hippocampal Neuronal Apoptosis in Chronic Cerebr [PMID:41879438] | Zhou L, Jia J, Li J, Yao Z, Fu Z, Wang S | Current neuropharmacology | 2026 | 0 |
| Mechanistic Modulation of Autophagy by Bioactive Natural Products: Implications [PMID:41830033] | Jalouli M, Harrath AH, Al-Zharani M, Rah | Nutrients | 2026 | 0 |
| Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in [PMID:41645754] | Li W, Wang WH, Song Y, Li XJ, Li Y et al | Int J Mol Med | 2026 | 0 |
| Unravelling the therapeutic potential of chrysin against ischemic stroke and pos [PMID:41687709] | Achar PG, Krishna KL, C P K, Patil M, Pr | Neuroscience | 2026 | 0 |
| Loss of REST associated with Alzheimer's disease pathology is ameliorated by NAD [PMID:41709697] | Lagartos-Donate MJ, Escobar-Doncel B, Zh | Brain | 2026 | 0 |
| SIRT1 Activators as Geroprotective Agents in Brain Aging: Mechanisms and Therape [PMID:41934491] | Alameen AAM, Al-Kuraishy HM, Al-Gareeb A | Neuromolecular Med | 2026 | 0 |
| Valsartan promotes neuroprotection in Parkinson's disease via epigenetic modulat [PMID:41936814] | Gowied HG, El-Mezayen NS, Afify EA | Life Sci | 2026 | 0 |
| [The Chinese medicine Gandouling attenuates brain injury in hepatolenticular deg [PMID:41946579] | Wu K, Wang N, Zhao D, Wei W, Zhang W et | Zhejiang Da Xue Xue Bao Yi Xue | 2026 | 0 |
| Insulin resistance and SIRT1 dysregulation in neurodegenerative diseases. [PMID:41759326] | Shah A, Doshi G | Ageing research reviews | 2026 | 0 |
| Urolithin A Reverses Intranigral Rotenone-Generated Parkinsonism by Modulating D [PMID:41880654] | Devi A, Singh SB, Srivastava S, Dandekar | ACS chemical neuroscience | 2026 | 0 |
| Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can [PMID:41902653] | Merlo S, Lipari CLR, Patti A, Sortino MA | Phytotherapy research : PTR | 2026 | 0 |
| Subtype-specific sirtuin expression signatures link mitochondrial-epigenetic net [PMID:41692938] | Ungvari Z, Menyhárt O, Ocana A, Lehoczki | GeroScience | 2026 | 0 |
| All the Way: A Decade of SIRT1 in Breast Cancer. [PMID:41898317] | Pratelli G, Montalbano M, Affranchi F, O | Biomedicines | 2026 | 0 |
| Therapeutic potential of sulforaphane in neurodegenerative diseases: mechanistic [PMID:41894075] | Kuwar OK, Tejpal S, Sharma V, Sharma A, | Molecular biology reports | 2026 | 0 |
| Uncovering the metabolic-epigenetic links between gene expression and stroke: in [PMID:41877258] | Kan J, Hong Y, Min R, Zhang B, Wang H | Neurological research and prac | 2026 | 0 |
| Dysregulation of SIRT1, polyamines and miRNA editing in cancer and aging. [PMID:41863647] | Ramamonjiharisoa MBM, Liu S | Amino acids | 2026 | 0 |
| Immune-metabolic positive feedback model in COPD: cross-mechanisms and potential [PMID:41869013] | Chen W, Huang S, He L, Zhou X, Li R, Wan | Frontiers in cell and developm | 2026 | 0 |
| Unraveling Network Pharmacology-Based Therapeutics of Anthranilate Sulfonamides [PMID:41714304] | Ruankham W, Prachayasittikul V, Pingaew | Journal of neurochemistry | 2026 | 0 |
| Advances and Therapeutic Potential of Anthraquinone Compounds in Neurodegenerati [PMID:41868184] | Liu Z, Zhang H, Wan B, Yin S, Yue R | Drug design, development and t | 2026 | 0 |