Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Stress granule / RNA granule assembly: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| G3BP1 | participates_in | gene | 0.46 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Phase-Separated Organelle Targeting | 0.521 | neurodegeneration | Microglia-astrocyte crosstalk amplificat |
| Stress Granule Phase Separation Modulators | 0.490 | neurodegeneration | RNA binding protein dysregulation across |
| RNA Granule Nucleation Site Modulation | 0.479 | neurodegeneration | TDP-43 phase separation therapeutics for |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.575
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3B [PMID:36692217] | Yang C, Wang Z, Kang Y, Yi Q, Wang T, Ba | Autophagy | 2023 | 3 |
| G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Gran [PMID:32302571] | Yang P, Mathieu C, Kolaitis RM, Zhang P, | Cell | 2020 | 3 |
| Organelle-specific autophagy in inflammatory diseases: a potential therapeutic t [PMID:32048886] | Yao RQ, Ren C, Xia ZF, Yao YM | Autophagy | 2021 | 2 |
| Hypoxia-driven phase separation of the PABP1/eIF4B complex forms stress granules [PMID:41780839] | Lin Z, Gao Y, Zhang Q, Yang S, Chen Y, D | Cancer Lett | 2026 | 1 |
| LINC00599 Promotes Pulmonary Hypertension via Liquid-Liquid Phase Separation Wit [PMID:40693377] | Wang Y, Yin L, Zheng S, Liu A, Liu C, Ba | Hypertension | 2025 | 1 |
| The important role of stress granules in prostate cancer development, progressio [PMID:40972860] | Xu Z, You H, Gu J, Jiang J, Yan Z, Jin X | Gene | 2025 | 1 |
| Membrane Atg8ylation, stress granule formation, and MTOR regulation during lysos [PMID:36394332] | Jia J, Wang F, Bhujabal Z, Peters R, Mud | Autophagy | 2023 | 1 |
| Role of stress granules in modulating senescence and promoting cancer progressio [PMID:34460104] | Chatterjee D, Chakrabarti O | Int J Cancer | 2022 | 1 |
| Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specifi [PMID:34739333] | Gwon Y, Maxwell BA, Kolaitis RM, Zhang P | Science | 2021 | 1 |
| STING is the scaffold protein for stress granule pre-condensation at the ER. [PMID:41917183] | Eom E, Kim J, Kim J, Kang SJ | Cell death and differentiation | 2026 | 0 |
| Stress granules: Guardians of cellular health and triggers of disease. [PMID:39995077] | ["Desai M", "Gulati K", "Agrawal M", "Gh | Neural regeneration research | 2026 | 0 |
| WFDC21P is essential for G3BP1-mediated RIG-I activation and antitumor immunity [PMID:41915747] | Li Z, Wang Y, Chen Z, Liu R, Lai ZH, Li | Proceedings of the National Ac | 2026 | 0 |
| NUP93 facilitates the nuclear import of SOX2 to activate G3BP1 transcription and [PMID:41896201] | Sun H, Yang C, Du J, Xu C, Chen Y, Chen | Cell death & disease | 2026 | 0 |
| Implications of virus-induced stress granules in tauopathies. [PMID:41673769] | Sharma S, Vandenakker A, Cortés-Pérez C, | Translational neurodegeneratio | 2026 | 0 |
| Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by sup [PMID:41920932] | Mulloy RP, Evseev D, Sharlin N, Bui-Mari | PLoS biology | 2026 | 0 |
| Stress granules at the crossroads of retroviral replication and antiviral immuni [PMID:41931190] | Akbarin MM, Farjami Z, Álvarez HR | Mol Biol Rep | 2026 | 0 |
| Proteolytic cleavage of G3BP1 by calpain 1 couples NMDAR activation to mTOR-depe [PMID:41935238] | Park DH, Ahn SY, Kim J, Choi J, Lee S et | EMBO Rep | 2026 | 0 |
| SARS-CoV-2 directly infects the inner ear and causes hearing dysfunction. [PMID:41936052] | Liu X, Zong Y, Liu K, Shi X, Zhao Z et a | Cell Rep | 2026 | 0 |
| Pharmacological modulation of stress granules via G3BP1/2: A pathway to treat ca [PMID:41924133] | Yang J, Gao F | Frontiers in pharmacology | 2026 | 0 |
| Targeting G3BP1-Mediated Stress Granules to Suppress SARS-CoV-2 Replication. [PMID:41960678] | Aromokeye R, Kuang L, Ackerman-Berrier M | ACS Infect Dis | 2026 | 0 |