gene

G3BP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about G3BP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1218Connections

4Hypotheses

10Analyses

50Outgoing

50Incoming

13Experiments

7Debates

Summary

G3BP1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with AD, ALI, ALS. Connected to 448 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	G3BP1
Full Name	Ras-GTPase-Activating Protein-Binding Protein 1
Chromosome	5q33.1
Protein Type	Signaling Protein
Target Class	Signaling Protein
Function	SG Nucleation: G3BP1 acts as a scaffold for SG assembly, recruiting other SG components
Mechanism of Action	G3BP1 inhibitors would prevent stress granule assembly and stabilization by disrupting the interaction between G3BP1 and its binding partners, potentially reducing pathological aggregation of TDP-43 and FUS proteins. This mechanism could alleviate neurodegeneration in conditions characterized by aberrant stress granule formation and RNA metabolism dysfunction.
Primary Expression	Ubiquitous, high in brain (neurons, glia)
Druggability	Medium (0.47)
Clinical Stage	Phase II
Molecular Weight	~52 kDa
Pathways	Apoptosis, Autophagy, Er Stress, Immune Response, Mtor
UniProt ID	A0A7I2V3C4
NCBI Gene ID	9973
Ensembl ID	ENSG00000130830
GeneCards	G3BP1
Human Protein Atlas	G3BP1
Associated Diseases	AD, ALI, Als, Alzheimer, AMI
Known Drugs/Compounds	axonal mRNA, EGCG, Intracellular Free Rna, rapamycin, trehalose
Interactions	ABCD3, ACTB, Actin, Akt, AKT, ALS
SciDEX Target	View Target Profile (7 clinical trials)
SciDEX Hypotheses	Phase-Separated Organelle Targeting Stress Granule Phase Separation Modulators RNA Granule Nucleation Site Modulation (+1 more)
KG Connections	1218 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — G3BP1 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

4FCJ — X-ray / Cryo-EM

🔮 AI Predicted Structure

A0A7I2V3C4 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

G3BP1

gene · 1167 words

→

G3BP1 Protein — Ras-GTPase-Activating Protein-Binding Protein 1

protein · 792 words

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Pathway Diagram

graph TD
    G3BP1["G3BP1"] -->|"associated"| neurodegeneration["neurodegeneration"]
    G3BP1["G3BP1"] -->|"co discussed"| SRPK1["SRPK1"]
    TGM2["TGM2"] -->|"co discussed"| G3BP1["G3BP1"]
    PRMT1["PRMT1"] -->|"co discussed"| G3BP1["G3BP1"]
    PARP1["PARP1"] -->|"co discussed"| G3BP1["G3BP1"]
    HSPA1A["HSPA1A"] -->|"co discussed"| G3BP1["G3BP1"]
    style G3BP1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (783)

Target	Relation	Type	Str
Stress Granules	associated_with	process	0.95
Liquid-Liquid Phase Separation	mediates	process	0.95
STRESS GRANULE ASSEMBLY	regulates	entity	0.95
Stress Granule Formation	mediates	process	0.95
Stress Granule Disassembly	mediates	process	0.95
STRESS GRANULE DISASSEMBLY	involved_in	entity	0.95
Stress Granule	component_of	organelle	0.95
LIQUID-LIQUID PHASE SEPARATION	mediates	entity	0.95
PI3K/Akt signaling	activates	pathway	0.95
Stress Granule Formation	involved_in	process	0.95
stress granule-like structures	involved_in	process	0.95
Stress Granules	promotes	process	0.95
stress granule formation	involved_in	process	0.95
immune evasion	promotes	process	0.94
SLU7	interacts_with	protein	0.92
Stress Granule Assembly	mediates	process	0.92
stress granules	activates	process	0.90
Ribonucleoprotein Granules	regulates	process	0.90
Stress Granule	involved_in	process	0.90
Stress Granules	activates	process	0.90
anti-PD-1 therapy response	risk_factor_for	phenotype	0.90
Stress Granules	mediates	process	0.90
AUTOPHAGY	involved_in	entity	0.90
LINC00599	interacts_with	gene	0.90
Stress Granules	component_of	structure	0.90
STRESS GRANULE-SPECIFIC INTERACTION NETWORK	regulates	entity	0.90
STRESS GRANULE	associated_with	biological_process	0.90
Stress Granule	interacts_with	cell_type	0.90
Liquid-Liquid Phase Separation	involved_in	process	0.90
axonal mRNA translation	inhibits	process	0.90
Intrinsically Disordered Regions	involved_in	mechanism	0.88
axonal mRNA	binds	compound	0.85
Prostate Cancer	upregulates	disease	0.85
MULTISYSTEM PROTEINOPATHY	implicated_in	entity	0.85
ALS	implicated_in	entity	0.85
FTD	implicated_in	entity	0.85
Stress Granule Interaction Network	regulates	pathway	0.85
NEURODEGENERATIVE DISEASES	implicated_in	entity	0.85
FAF2	interacts_with	protein	0.85
MYH9	interacts_with	protein	0.85
stress_granules	associated_with	entity	0.80
autophagy pathway	participates_in	pathway	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
cell apoptosis	regulates	process	0.80
neural stem cells	regulates	cell_type	0.80
axonal mRNA translation	limits	process	0.80
nerve regeneration	limits	process	0.80
Stress Response	involved_in	process	0.80
NF-κB	regulates	pathway	0.80
stress_granule_formation	controls	pathway	0.80

Incoming (435)

Source	Relation	Type	Str
Ubiquitination	modulates	process	0.95
UBIQUITINATION	modulates	entity	0.95
Nsp3	binds	protein	0.95
TRIM21	phosphorylates	protein	0.95
hiPSC-derived lung organoid	expressed_in	cell_type	0.95
UBIQUITIN	mediates	entity	0.95
h-ec731b7a	targets_gene	hypothesis	0.90
h-fffd1a74	targets_gene	hypothesis	0.90
h-97aa8486	targets_gene	hypothesis	0.90
TRIM21	catalyzes_ubiquitination	gene	0.90
TRIM21	ubiquitinates	protein	0.90
LINC00599	interacts_with	gene	0.90
PHOSPHORYLATION	modulates	entity	0.90
h-27bc0569	targets_gene	hypothesis	0.90
Intracellular Free Rna	activates	compound	0.90
ubiquitination	regulates	process	0.90
EGCG	inhibits	drug	0.89
Phosphorylation	modulates	process	0.85
Heat Shock	associated_with	phenotype	0.85
axotomy	modulates	process	0.85
Prrc2A	interacts_with	protein	0.85
Prrc2C	interacts_with	protein	0.85
Prrc2B	interacts_with	protein	0.85
h-fffd1a74	targets	hypothesis	0.80
h-ec731b7a	targets	hypothesis	0.80
h-97aa8486	targets	hypothesis	0.80
TRIM21	associated_with	protein	0.80
SQSTM1	binds	gene	0.80
STING	interacts_with	gene	0.80
CALCOCO2/NDP52	interacts_with	protein	0.80
SQSTM1/p62	interacts_with	protein	0.80
ALS	regulates	gene	0.70
BECN1	regulates	gene	0.70
CALCOCO2	regulates	gene	0.70
ATG	regulates	gene	0.70
ATG	activates	gene	0.70
STAT3	activates	gene	0.60
MAVS	inhibits	gene	0.60
IRF3	inhibits	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
NPM1	therapeutic_target	gene	0.60
HNRNPA1	associated_with	gene	0.60
C9ORF72	associated_with	gene	0.60
DRP1	activates	entity	0.60
TAU	interacts_with	gene	0.60
EPAS1	activates	entity	0.60
CTSD	regulates	gene	0.60
DRP1	regulates	gene	0.60
AMPK	regulates	gene	0.60
RAC1	regulates	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Phase-Separated Organelle Targeting	0.729	neurodegeneration	Microglia-astrocyte crosstalk amplificat
Stress Granule Phase Separation Modulators	0.720	neurodegeneration	RNA binding protein dysregulation across
RNA Granule Nucleation Site Modulation	0.662	neurodegeneration	TDP-43 phase separation therapeutics for
Liquid-Liquid Phase Separation Modifier Therapy	0.656	neurodegeneration	Protein aggregation cross-seeding across

Mentioning Analyses (10)

Scientific analyses that reference this entity

Experiments (13)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
TRIM21-mediated K63-linked ubiquitination of G3BP1	exploratory		0.950	0.00	in vitro biochemical assays, c	proposed	N/A
G3BP1-mediated stress granule assembly via liquid-liquid phase separat	exploratory		0.900	0.00	eukaryotic cells	proposed	N/A
G3BP1 intrinsically disordered region analysis and phosphorylation eff	exploratory		0.850	0.00	in vitro protein analysis syst	proposed	N/A
G3BP1-binding factor cooperativity in stress granule network regulatio	exploratory		0.800	0.00	cell culture systems with prot	proposed	N/A
Proposed experiment from debate on TDP-43 undergoes liquid-liquid phas	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FTD	validation	ALS	0.400	0.50	human	proposed	$2,730,000
C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study	clinical	ALS	0.400	0.50	human	proposed	$6,550,000
Pre-Symptomatic Detection and Intervention Timing in Genetic Prion Dis	validation	ALS	0.400	0.50	human	proposed	$2,280,000
Stress Granule Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Experiment Validation: In vitro ThT Assay	validation	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$160,000
Mutant Huntingtin (mHTT) Clearance Mechanisms — Therapeutic Target Val	validation	Neurodegeneration	0.400	0.50	human	proposed	$3,000,000
Multiscale Computational Modeling of Protein Aggregation Kinetics	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,280,000
Protein Aggregation Kinetic Validation Results	validation	Neurodegeneration	0.400	0.50	in_silico	proposed	$120,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3B [PMID:36692217]	Yang C, Wang Z, Kang Y, Yi Q, Wang T, Ba	Autophagy	2023	3
G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Gran [PMID:32302571]	Yang P, Mathieu C, Kolaitis RM, Zhang P,	Cell	2020	3
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic t [PMID:32048886]	Yao RQ, Ren C, Xia ZF, Yao YM	Autophagy	2021	2
Hypoxia-driven phase separation of the PABP1/eIF4B complex forms stress granules [PMID:41780839]	Lin Z, Gao Y, Zhang Q, Yang S, Chen Y, D	Cancer Lett	2026	1
LINC00599 Promotes Pulmonary Hypertension via Liquid-Liquid Phase Separation Wit [PMID:40693377]	Wang Y, Yin L, Zheng S, Liu A, Liu C, Ba	Hypertension	2025	1
The important role of stress granules in prostate cancer development, progressio [PMID:40972860]	Xu Z, You H, Gu J, Jiang J, Yan Z, Jin X	Gene	2025	1
Membrane Atg8ylation, stress granule formation, and MTOR regulation during lysos [PMID:36394332]	Jia J, Wang F, Bhujabal Z, Peters R, Mud	Autophagy	2023	1
Role of stress granules in modulating senescence and promoting cancer progressio [PMID:34460104]	Chatterjee D, Chakrabarti O	Int J Cancer	2022	1
Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specifi [PMID:34739333]	Gwon Y, Maxwell BA, Kolaitis RM, Zhang P	Science	2021	1
STING is the scaffold protein for stress granule pre-condensation at the ER. [PMID:41917183]	Eom E, Kim J, Kim J, Kang SJ	Cell death and differentiation	2026	0
Stress granules: Guardians of cellular health and triggers of disease. [PMID:39995077]	["Desai M", "Gulati K", "Agrawal M", "Gh	Neural regeneration research	2026	0
WFDC21P is essential for G3BP1-mediated RIG-I activation and antitumor immunity [PMID:41915747]	Li Z, Wang Y, Chen Z, Liu R, Lai ZH, Li	Proceedings of the National Ac	2026	0
NUP93 facilitates the nuclear import of SOX2 to activate G3BP1 transcription and [PMID:41896201]	Sun H, Yang C, Du J, Xu C, Chen Y, Chen	Cell death & disease	2026	0
Implications of virus-induced stress granules in tauopathies. [PMID:41673769]	Sharma S, Vandenakker A, Cortés-Pérez C,	Translational neurodegeneratio	2026	0
Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by sup [PMID:41920932]	Mulloy RP, Evseev D, Sharlin N, Bui-Mari	PLoS biology	2026	0
PRRC2A, PRRC2B and PRRC2C are Stress Granule Proteins that Promote Translation T [PMID:41808986]	["Huang J", "Kadijk E", "Schreiber K", "	bioRxiv : the preprint server	2026	0
Rainbow trout (Oncorhynchus mykiss) G3BP1 function as an antiviral molecule agai [PMID:41831384]	["Zhao J", "Shao Y", "Liu W", "Lu T", "X	Fish & shellfish immunology	2026	0
Stress granules at the crossroads of retroviral replication and antiviral immuni [PMID:41931190]	Akbarin MM, Farjami Z, Álvarez HR	Mol Biol Rep	2026	0
Tetramethylthiuram disulfide induces stress granules and DNA damage through oxid [PMID:41822241]	["Lin M", "Lee S", "Gwak J", "Cha J", "H	Animal cells and systems	2026	0
Androgen receptor localisation and protein interactions provide insight into ste [PMID:41844688]	["Bleach R", "Bozkurt E", "Xin J", "Shee	NPJ breast cancer	2026	0

Debates (7)

Multi-agent debates referencing this entity

G3BP1

Understanding Entity Pages

Summary

Wiki Pages (2)

G3BP1

G3BP1 Protein — Ras-GTPase-Activating Protein-Binding Protein 1

Pathway Diagram

Outgoing (783)

Incoming (435)

Targeting Hypotheses (4)

Mentioning Analyses (10)

What determines the spatial organization of autophagy receptors at stress granul

What determines the specificity of RNA-protein interactions that drive distinct

How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit liq

How do pathological stress granules transition from reversible to persistent in

How do pathological stress granules in neurodegeneration escape TRIM21/autophagy

How do disease-associated mutations in G3BP1 or its binding partners alter stres

RNA binding protein dysregulation across ALS FTD and AD

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

TDP-43 phase separation therapeutics for ALS-FTD

Protein aggregation cross-seeding across neurodegenerative diseases

Experiments (13)

Related Papers (20)

Debates (7)

Protein aggregation cross-seeding across neurodegenerative diseases?

RNA binding protein dysregulation across ALS FTD and AD

TDP-43 undergoes liquid-liquid phase separation that becomes pathological. Small

TDP-43 phase separation therapeutics for ALS-FTD

Microglia activate astrocytes via IL-1alpha/TNF/C1q, and reactive astrocytes fee

Analysis question not specified

RNA binding protein dysregulation across ALS FTD and AD