gene

TAAR6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAAR6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Trace amine-associated receptor 6 gene involved in monoamine signaling and neuropsychiatric disorders

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🧬 Gene Info

Gene Symbol	TAAR6
Chromosome	6q23.2
Protein Type	Gene
Function	is a member of the trace amine-associated receptor (TAAR) family of G protein-coupled receptors.
Primary Expression	brain regions associated with emotional processing and motor control, where it modulates monoaminergic neurotransmission
Amino Acids	361 aa
GeneCards	TAAR6
Human Protein Atlas	TAAR6
N-terminus	Short extracellular domain with potential glycosylation sites
Transmembrane domains	Seven hydrophobic helices (TM1-TM7) that form the ligand-binding pocket
C-terminus	Intracellular tail with serine/threonine residues for phosphorylation
Conserved motifs	DRY motif in TM3 and NPxxY motif in TM7 are conserved
Olfactory bulb	High expression, consistent with a role in olfactory signal processing
Hippocampus	Moderate expression in pyramidal cell layers
Amygdala	Expression in nuclei involved in emotional processing
Associated Diseases	Parkinson's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TAAR6 Gene

gene · 989 words

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Pathway Diagram

graph TD
    TAAR6["TAAR6"]
    neurodegeneration["neurodegeneration"]
    TAAR6 -->|"implicated_in"| neurodegeneration
    style TAAR6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning TAAR6 in their description or question text

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