gene

TCF4_GENE

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about TCF4_GENE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

TCF4 Gene

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🧬 Gene Info

Gene Symbol	TCF4-GENE
Aliases	TCF4_GENE
Chromosome	18q21.2
Protein Type	Transcription Factor
Function	is a basic helix-loop-helix (bHLH) transcription factor encoded by the TCF4 gene on chromosome 18q21.
Primary Expression	the developing brain, with persistent expression in adulthood particularly in: - Hippocampal CA1-CA3 regions - Cerebral cortex (layer 2/3 pyramidal ne
Amino Acids	010 aa
Exons	20
GeneCards	TCF4-GENE
Human Protein Atlas	TCF4-GENE
bHLH DNA-binding domain	Recognizes E-box consensus sequences (CANNTG)
C-terminal dimerization domain	Mediates heterodimer formation with other bHLH proteins
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TCF4 Gene

gene · 674 words

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Pathway Diagram

graph TD
    TCF4_GENE["TCF4_GENE"]
    neurodegeneration["neurodegeneration"]
    TCF4_GENE -->|"implicated_in"| neurodegeneration
    style TCF4_GENE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning TCF4_GENE in their description or question text

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