Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TDP-43 phase separation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Splicing regulation | regulates | process | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DPR_proteins | disrupts | protein | 0.90 |
| RNA | modulates | pathway | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| RNA-binding protein condensate maturation from reversible ph | 0.626 | neurodegeneration | Biophysical Determinants Shifting FUS/TD |
| Cell-state stratification is required to resolve Biophysical | 0.612 | neurodegeneration | Biophysical Determinants Shifting FUS/TD |
| Perturbation-first validation should precede therapeutic cla | 0.608 | neurodegeneration | Biophysical Determinants Shifting FUS/TD |
| TDP-43 Phase Separation Destabilization Drives Cytoplasmic A | 0.500 | neurodegeneration | Test |
| Targeting TDP-43 Phase Separation Through Selective RNA-Bind | 0.000 | - | - |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-27 | 4 hypotheses Top: 0.680
medicinal chemistry | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-01 | 18 hypotheses Top: 0.738
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.67 · 2026-04-28
closed · Rounds: 4 · Score: 0.43 · 2026-04-21
closed · Rounds: 6 · Score: 0.84 · 2026-04-12
closed · Rounds: 4 · Score: 0.95 · 2026-04-11
Hypotheses and analyses mentioning TDP-43 phase separation in their description or question text
No additional research found