Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TDP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive page on TDP2, a DNA repair enzyme that removes topoisomerase II-mediated DNA damage and plays critical roles in neuronal survival and neurodegenerative diseases.
| Gene Symbol | TDP2 |
| Full Name | Tyrosyl-DNA Phosphodiesterase 2 |
| Chromosome | 6p22.3 |
| Protein Type | Enzyme |
| Function | is a critical DNA repair enzyme specialized in resolving topoisomerase II (TOP2)-induced DNA damage. |
| Molecular Weight | 40.5 kDa |
| Amino Acids | 362 aa |
| Exons | 9 |
| UniProt ID | [Q9H2P2](https://www.uniprot.org/uniprot/Q9H2P2) |
| Ensembl ID | ENSG00000111802 |
| OMIM | 614675 |
| GeneCards | TDP2 |
| Human Protein Atlas | TDP2 |
| Chemical inhibitors | Etoposide, doxorubicin, and anthracycline chemotherapeutics stabilize the cleavage complex |
| Endogenous stress | Reactive oxygen species (ROS) can oxidize TOP2, stabilizing its covalent linkage to DNA |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TDP2["TDP2"]
neurodegeneration["neurodegeneration"]
TDP2 -->|"implicated_in"| neurodegeneration
style TDP2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| No outgoing edges | |||
| Source | Relation | Type | Str |
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| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||