protein

TFR2PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TFR2PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Transferrin receptor 2 (TFR2) is a transmembrane protein that mediates cellular iron uptake and plays a critical role in systemic iron homeostasis.

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🔬 Protein Info

Gene Symbol	TFR2PROTEIN
Function	is a transmembrane protein that mediates cellular iron uptake and plays a critical role in systemic iron homeostasis.
Primary Expression	hepatocytes and is essential for hepcidin regulation[@wallace2007]: - Forms a complex with HFE (hereditary hemochromatosis protein) - HFE-TFR2 complex
Amino Acids	801 aa
GeneCards	TFR2PROTEIN
Human Protein Atlas	TFR2PROTEIN
Protein	Interaction
HFE	Complex formation
[Transferrin](/proteins/transferrin-protein)	Ligand binding
[Hepcidin](/proteins/hepcidin-protein)	Induced by TFR2 signaling
BMP receptors	Co-signaling
[Ferroportin](/proteins/ferroportin-protein)	Regulated via hepcidin
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Transferrin Receptor 2

protein · 857 words

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Pathway Diagram

graph TD
    TFR2PROTEIN["TFR2PROTEIN"]
    neurodegeneration["neurodegeneration"]
    TFR2PROTEIN -->|"implicated_in"| neurodegeneration
    style TFR2PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

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