| Gene Symbol | TFR2PROTEIN |
| Function | is a transmembrane protein that mediates cellular iron uptake and plays a critical role in systemic iron homeostasis. |
| Primary Expression | hepatocytes and is essential for hepcidin regulation[@wallace2007]:
- Forms a complex with HFE (hereditary hemochromatosis protein)
- HFE-TFR2 complex |
| Amino Acids | 801 aa |
| GeneCards | TFR2PROTEIN |
| Human Protein Atlas | TFR2PROTEIN |
| Protein | Interaction |
| HFE | Complex formation |
| [Transferrin](/proteins/transferrin-protein) | Ligand binding |
| [Hepcidin](/proteins/hepcidin-protein) | Induced by TFR2 signaling |
| BMP receptors | Co-signaling |
| [Ferroportin](/proteins/ferroportin-protein) | Regulated via hepcidin |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |