Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TIC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | TIC1 |
| Full Name | Transcriptional Intermediary Factor 1 |
| Chromosome | 2p23.3 |
| Protein Type | Receptor |
| Function | is a nuclear receptor coactivator that plays a critical role in transcriptional regulation. |
| UniProt ID | Q13448 |
| Ensembl ID | ENSG00000100994 |
| OMIM | 603484 |
| GeneCards | TIC1 |
| Human Protein Atlas | TIC1 |
| Nuclear receptor interaction | Binds to ligand-bound nuclear receptors including estrogen receptor (ER), progesterone receptor (PR), thyroid hormone receptor (TR), and retinoic acid receptor (RAR) |
| Histone acetylation recruitment | Recruits p300/CBP histone acetyltransferases to chromatin |
| Chromatin remodeling | Attracts SWI/SNF complexes for nucleosome displacement |
| Mediator complex recruitment | Facilitates interaction between transcription factors and RNA polymerase II |
| PAS domains (PAS-A, PAS-B) | Protein-protein interactions and signal sensing |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TIC1["TIC1"]
neurodegeneration["neurodegeneration"]
TIC1 -->|"implicated_in"| neurodegeneration
style TIC1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TIC1 in their description or question text
No additional research found