protein

TPPPPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TPPPPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	TPPPPROTEIN
Function	is a 219 amino acid intrinsically disordered protein that stabilizes microtubules and promotes tubulin acetylation in oligodendrocytes.
Subcellular Localization	</td><td>Cytoplasm (perinuclear, cell processes in oligodendrocytes)</td></tr>
Molecular Weight	24 kDa
GeneCards	TPPPPROTEIN
Human Protein Atlas	TPPPPROTEIN
GTPase active site	The Walker A motif (GxxxxGK) and Walker B motif (DxxG) enable GTP hydrolysis with Km ~ 30 μM, similar to small GTPases
TPPP2	Testis-specific
TPPP3/p20	Broader tissue expression, ciliary function
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TPPP/p25alpha Protein

protein · 926 words

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Pathway Diagram

graph TD
    TPPPPROTEIN["TPPPPROTEIN"]
    neurodegeneration["neurodegeneration"]
    TPPPPROTEIN -->|"implicated_in"| neurodegeneration
    style TPPPPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning TPPPPROTEIN in their description or question text

No additional research found