Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TREM3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | TREM3 |
| Full Name | Triggering Receptor Expressed on Myeloid Cells 3 |
| Chromosome | 6p21.1 |
| Protein Family | TREM family (Immunoglobulin superfamily) |
| Protein Type | Receptor |
| Function | is a member of the TREM family of immunoreceptors that play critical roles in innate immune signaling. |
| Primary Expression | cells of myeloid lineage: |
| Molecular Weight | 12 kDa |
| Gene Type | Protein coding |
| UniProt ID | Q9NYC5 |
| NCBI Gene ID | 54206 |
| Ensembl ID | ENSG00000177453 |
| OMIM | 605538 |
| GeneCards | TREM3 |
| Human Protein Atlas | TREM3 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TREM3["TREM3"]
neurodegeneration["neurodegeneration"]
TREM3 -->|"implicated_in"| neurodegeneration
style TREM3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||