gene 2,432 words KG: TREM3 2026-03-27
kind:genesection:genesstate:published
Contents

Triggering Receptor Expressed on Myeloid Cells 3 (TREM3)

🧬 Gene Info
Gene SymbolTREM3
Full NameTriggering Receptor Expressed on Myeloid Cells 3
Chromosome6p21.1
Protein FamilyTREM family (Immunoglobulin superfamily)
Protein TypeReceptor
Functionis a member of the TREM family of immunoreceptors that play critical roles in innate immune signaling.
Primary Expressioncells of myeloid lineage:
Molecular Weight12 kDa
Gene TypeProtein coding
UniProt IDQ9NYC5
NCBI Gene ID54206
Ensembl IDENSG00000177453
OMIM605538
GeneCardsTREM3
Human Protein AtlasTREM3
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (22)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62

Related Analyses (7)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

Related Experiments (14)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 3 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 3 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 3 hypotheses