gene

TRIM9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRIM9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

1Analyses

2Outgoing

0Incoming

0Experiments

1Debates

Summary

TRIM9 (Tripartite Motif Containing 9) — brain-specific E3 ubiquitin ligase regulating synaptic development, axon guidance, neuroinflammation, and protein quality control in neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	TRIM9
Aliases	Tripartite Motif Containing 9
Chromosome	14q11.2
Protein Type	Gene
Function	is a brain-specific E3 ubiquitin ligase with critical functions in synaptic development, axon guidance, neuroimmune responses, and protein quality control.
Primary Expression	the olfactory bulb, hippocampus, cerebral cortex, and [cerebel
Molecular Weight	52 kDa
Amino Acids	462 aa
GeneCards	TRIM9
Human Protein Atlas	TRIM9
Associated Diseases	neurodegeneration
KG Connections	2 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TRIM9 Gene

gene · 1392 words

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Pathway Diagram

graph TD
    TRIM9["TRIM9"]
    neurodegeneration["neurodegeneration"]
    TRIM9 -->|"implicated_in"| neurodegeneration
    style TRIM9 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (2)

Target	Relation	Type	Str
VASP	regulates	protein	0.70
filopodia formation	regulates	process	0.70

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do astrocytes functionally express TRIM46, and can PKCα phosphorylate it to driv

molecular biology | 2026-04-13 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The P2X7 hypothesis relies on TRIM46-mediated actin polymerization in astrocytes

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

Related Research

Hypotheses and analyses mentioning TRIM9 in their description or question text

No additional research found