gene

TRPM4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRPM4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

TRPM4 (Transient Receptor Potential Cation Channel Subfamily M Member 4) is a calcium-activated non-selective cation channel involved in cardiac conduction, immune cell activation, and neurological processes.

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🧬 Gene Info

Gene Symbol	TRPM4
Aliases	Transient Receptor Potential Cation Channel Subfamily M Member 4
Protein Type	Channel
Function	Calcium activation — Intracellular Ca²⁺ directly activates TRPM4, with activation threshold around 1-10 μM
Primary Expression	numerous tissues including the heart, immune system, and brain
Molecular Weight	134 kDa
Ensembl ID	ENSG00000130589
GeneCards	TRPM4
Human Protein Atlas	TRPM4
Intracellular calcium	Primary activator
Voltage	Depolarization increases open probability
Phosphorylation	PKC and CaM kinase II can modulate activity
ATP	Intracellular ATP can inhibit the channel
pH	Intracellular pH affects channel function
Calmodulin	Mediates Ca²⁺-dependent activation
Associated Diseases	Parkinson's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TRPM4 Gene

gene · 2747 words

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TRPM4 Protein

protein · 640 words

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Pathway Diagram

graph TD
    TRPM4["TRPM4"]
    neurodegeneration["neurodegeneration"]
    TRPM4 -->|"implicated_in"| neurodegeneration
    style TRPM4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning TRPM4 in their description or question text

No additional research found