gene

TRPM6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRPM6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Magnesium-permeable ion channel essential for magnesium homeostasis and neuronal function

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🧬 Gene Info

Gene Symbol	TRPM6
Full Name	Transient Receptor Potential Cation Channel Subfamily M Member 6
Aliases	Transient Receptor Potential Melastatin 6
Chromosome	9q21.13
Protein Family	TRP melastatin channel family
Protein Type	Channel
Function	is a highly selective magnesium-permeable ion channel that plays a critical role in systemic and cellular magnesium homeostasis.
Molecular Weight	230 kDa
Amino Acids	128 aa
Exons	39
UniProt ID	[Q9BX63](https://www.uniprot.org/uniprot/Q9BX63)
Ensembl ID	ENSG00000106069
GeneCards	TRPM6
Human Protein Atlas	TRPM6
FOXO1 binding sites	Respond to cellular energy status
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TRPM6 — Transient Receptor Potential Cation Channel Subfamily M Member 6

gene · 2186 words

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TRPM6 Protein

protein · 1622 words

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Pathway Diagram

flowchart TD
    A["Upstream Regulators"] --> B["TRPM6"]
    B --> C["Molecular Mechanism"]
    C --> D["Cellular Effects"]
    D --> E["Pathological Consequences"]

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning TRPM6 in their description or question text

No additional research found