gene 2,186 words KG: TRPM6 2026-03-27
kind:genesection:genesstate:published
Contents

TRPM6 — Transient Receptor Potential Cation Channel Subfamily M Member 6

🧬 Gene Info
Gene SymbolTRPM6
Full NameTransient Receptor Potential Cation Channel Subfamily M Member 6
AliasesTransient Receptor Potential Melastatin 6
Chromosome9q21.13
Protein FamilyTRP melastatin channel family
Protein TypeChannel
Functionis a highly selective magnesium-permeable ion channel that plays a critical role in systemic and cellular magnesium homeostasis.
Molecular Weight230 kDa
Amino Acids128 aa
Exons39
UniProt ID[Q9BX63](https://www.uniprot.org/uniprot/Q9BX63)
Ensembl IDENSG00000106069
GeneCardsTRPM6
Human Protein AtlasTRPM6
FOXO1 binding sitesRespond to cellular energy status
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
APOE-Dependent Autophagy Restoration
Score: 0.61
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Mechanosensitive Ion Channel Reprogramming
Score: 0.51

Related Analyses (8)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in