Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TXN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | TXN2 |
| Full Name | Thioredoxin 2 |
| Chromosome | 22q12.3 |
| Protein Type | Oxidoreductase |
| Function | is a mitochondrial member of the thioredoxin family of oxidoreductases that plays a central role in maintaining cellular redox homeostasis[@holmgren1989]. |
| Amino Acids | 60 aa |
| Ensembl ID | ENSG00000100367 |
| GeneCards | TXN2 |
| Human Protein Atlas | TXN2 |
| Thioredoxin domain | Contains the canonical CXXC active site motif (CGPC) |
| Catalytic cysteines | Cys93 and Cys96 for disulfide/dithiol exchange |
| Peroxiredoxin reduction | Regenerates reduced PRDX3 after peroxide reduction |
| Protein disulfide reduction | Reduces oxidized mitochondrial proteins |
| Redox signaling | Controls local H₂O₂ concentrations and redox-sensitive signaling[@arnr2000] |
| TXN2 | Primary electron donor |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TXN2["TXN2 (Thioredoxin 2)"]
ROS["Reactive Oxygen Species"]
Mito["Mitochondrial Dysfunction"]
GPX4["GPX4 (Glutathione Peroxidase 4)"]
Ferro["Ferroptosis"]
LipidPer["Lipid Peroxidation"]
IronAcc["Iron Accumulation"]
NeuroDegeneration["Neurodegeneration"]
ALS["ALS"]
AD["Alzheimer's Disease"]
PD["Parkinson's Disease"]
PRDX3["PRDX3 (Peroxiredoxin 3)"]
GSH["Glutathione System"]
CellDeath["Neuronal Cell Death"]
Antioxidant["Antioxidant Defense"]
TXN2 -->|"reduces"| ROS
TXN2 -->|"maintains"| Antioxidant
TXN2 -->|"supports"| GPX4
TXN2 -->|"activates"| PRDX3
TXN2 -->|"protects against"| Ferro
ROS -->|"causes"| LipidPer
ROS -->|"leads to"| Mito
LipidPer -->|"triggers"| Ferro
IronAcc -->|"promotes"| Ferro
GPX4 -->|"prevents"| LipidPer
Ferro -->|"causes"| CellDeath
Mito -->|"contributes to"| NeuroDegeneration
CellDeath -->|"leads to"| NeuroDegeneration
NeuroDegeneration -->|"manifests as"| ALS
NeuroDegeneration -->|"manifests as"| AD
NeuroDegeneration -->|"manifests as"| PD
classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#fff
classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#fff
classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#fff
class TXN2 central
class GPX4,PRDX3,GSH,Antioxidant protective
class ROS,Mito,Ferro,LipidPer,IronAcc,CellDeath,NeuroDegeneration pathological
class ALS,AD,PD disease| Target | Relation | Type | Str |
|---|---|---|---|
| Ferroptosis | protects_against | process | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| ATXN2 Antisense Oligonucleotides Reduce Dipeptide Repeat Pro | 0.630 | neurodegeneration | Test |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TXN2 in their description or question text
No additional research found