Toxicity

What are the mechanisms underlying apoe4 structural biology and therapeutic targ

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

What are the mechanisms underlying protein aggregation cross-seeding across neur

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

What are the mechanisms underlying epigenetic clocks and biological aging in neu

closed · Rounds: 4 · Score: 0.88 · 2026-04-01

C9orf72 repeat RNA and dipeptide-repeat toxicity in ALS/FTD

Score: 0.700 · neurodegeneration · 2026-04-29

C9orf72 hexanucleotide repeat expansion produces repeat RNA foci and RAN-translated dipeptide-repeat proteins that disru

DLK MAPK Pathway Inhibition to Block Tau-Induced Neurotoxicity Without Directly

Score: 0.634 · neurodegeneration · 2026-04-15

## Mechanistic Overview DLK MAPK Pathway Inhibition to Block Tau-Induced Neurotoxicity Without Directly Targeting Tau st

Subtle NMDAR Inhibition Attenuates Excitotoxicity-Driven Tau Release from Hypers

Score: 0.620 · neurodegeneration · 2026-04-22

## Mechanistic Overview Subtle NMDAR Inhibition Attenuates Excitotoxicity-Driven Tau Release from Hypersynchronized Circ

Microglial xCT/SLC7A11 Selective Inhibition to Reduce Non-Cell-Autonomous Glutam

Score: 0.620 · unknown disease · 2026-04-16

**Molecular Mechanism and Rationale** The system xc- transporter, composed of the light chain xCT (SLC7A11) and the hea

Neuropeptide Y (NPY) Co-release from PV Interneurons Modulates Aβ Toxicity

Score: 0.585 · alzheimers · 2026-04-28

PV interneurons co-release NPY, which signals via Y1 receptors on excitatory terminals to suppress glutamate release and

Gut Bacterial Metabolite-AhR Dysregulation Converts SCFA-Deficiency into IDO1-Dr

Score: 0.580 · neurodegeneration · 2026-04-26

Aryl hydrocarbon receptor (AhR), expressed in microglia, astrocytes, and neurons, normally ligates tryptophan catabolite

Small-Molecule FUS Nuclear Import Correctors Rescue Motor Neuron Toxicity

Score: 0.550 · neurodegeneration · 2026-04-26

ALS-linked FUS mutations (P525L, R521C) impair nuclear import via karyopherin-β2 (Transportin-1), causing cytoplasmic ac

TLR2 Recognition of Gut-Derived Fungal and Bacterial D-Alanylated Lipoteichoic A

Score: 0.550 · neurodegeneration · 2026-04-26

Dysbiosis permits overgrowth of SIBO species and opportunistic fungi (Candida albicans, Malassezia) whose cell wall comp

Synaptic NMDAR Subtype Targeting Prevents Excitotoxicity

Score: 0.520 · neurodegeneration · 2026-04-28

Selective GluN2A activation or GluN2B inhibition shifts balance from excitotoxic extrasynaptic signaling toward neuropro

Mitochondrial Dysfunction Increasing Neuronal Vulnerability to TDP-43 Toxicity

Score: 0.470 · neurodegeneration · 2026-04-21

## Mechanistic Overview Mitochondrial Dysfunction Increasing Neuronal Vulnerability to TDP-43 Toxicity starts from the c

Amyloid first impairs cholinergic terminals through alpha7 nicotinic receptor-de

Score: 0.450 · neurodegeneration · 2026-04-25

Soluble amyloid oligomers may injure cholinergic terminals via CHRNA7-linked calcium dysregulation, making cholinergic d