Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about domain_interaction: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| lipid_binding | prevents | process | 0.70 |
| toxicity | causes | phenotype | 0.70 |
| lipid binding | inhibits | process | 0.70 |
| lipid transport function | regulates | phenotype | 0.70 |
| amyloid clearance | inhibits | process | 0.50 |
| neurodegeneration | causes | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE4 | causes | protein_variant | 0.80 |
| APOE4_C112R | causes | protein | 0.70 |
| C112R mutation | causes | mutation | 0.70 |
| small molecule chaperones | prevents | drug | 0.50 |
| competitive peptides | prevents | drug | 0.50 |
| lipid mimetics | prevents | drug | 0.50 |
| small_molecule_chaperones | prevents | drug | 0.50 |
| glycan_modifications | prevents | process | 0.50 |
| interfacial_lipid_mimetics | prevents | drug | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Interfacial Lipid Mimetics to Disrupt Domain Interaction | 0.723 | neurodegeneration | APOE4 structural biology and therapeutic |
| Peptide Mimetics to Block Domain Interaction | 0.000 | - | APOE4 structural biology and therapeutic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.795
neurodegeneration | 2026-04-01 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| RBG treatment in ApoE-/- atherosclerosis mouse model | validation | atherosclerosis | 0.900 | 0.00 | ApoE-/- mice | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| The cell biology of APOE in the brain. [PMID:37805344] | Windham IA, Cohen S | Trends Cell Biol | 2024 | 1 |
| APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia. [PMID:33658354] | Sienski G, Narayan P, Bonner JM, Kory N, | Sci Transl Med | 2021 | 1 |
| APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therape [PMID:33340485] | Serrano-Pozo A, Das S, Hyman BT | Lancet Neurol | 2021 | 1 |
| Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. [PMID:31564456] | Long JM, Holtzman DM | Cell | 2019 | 1 |
| Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. [PMID:31367008] | Yamazaki Y, Zhao N, Caulfield TR, Liu CC | Nat Rev Neurol | 2019 | 1 |
| Perioperative polygenic and APOE-based genetic risk assessment for neurocognitiv [PMID:40562635] | Thedim M, Hu J, Maher M, Wiener-Kronish | Br J Anaesth | 2026 | 0 |
| Increased genetic protection against Alzheimer's disease in centenarians. [PMID:40615639] | Bae H, Song Z, Ali A, Sasaki T, Tesi N e | Geroscience | 2026 | 0 |
| Integrative machine learning approach to risk prediction for dementia and Alzhei [PMID:40864401] | Stern A, Linial M | Geroscience | 2026 | 0 |
| Adipose Tissue Macrophage-Derived Proplatelet Basic Protein Exacerbates Psoriasi [PMID:40886963] | Zhu L, Du L, Wu J, Ding D, Wang J et al. | J Invest Dermatol | 2026 | 0 |
| Restoration of p53 mRNA combined with BRD4 silencing by brain targeted nanocapsu [PMID:41101204] | Sang Y, Cao Y, Li S, Quan Y, Wang S et a | Biomaterials | 2026 | 0 |
| HTRA1 and Brain Disorders: A Balancing Act Across Neurodegeneration and Repair. [PMID:41932381] | Hjæresen S, Gramkow ET, Zhang M, Svennin | Prog Neurobiol | 2026 | 0 |
| Neuropsychiatric symptoms and apolipoprotein E genotypes in neurocognitive disor [PMID:40145985] | Lozupone M, Leccisotti I, Mollica A, Ber | Neural regeneration research | 2026 | 0 |
| Assessment of the Spatial Distribution of Moisture Content in Granular Material [PMID:31234567] | ["Porzuczek J"] | Sensors (Basel, Switzerland) | 2024 | 0 |
| Updates in Alzheimer's disease: from basic research to diagnosis and therapies. [PMID:39232848] | Liu E, Zhang Y, Wang JZ | Transl Neurodegener | 2024 | 0 |
| Updates in Alzheimer's disease: from basic research to diagnosis and therapies. [PMID:39232848] | Liu E, Zhang Y, Wang JZ | Translational neurodegeneratio | 2024 | 0 |
| Long-term polystyrene nanoplastic exposure disrupt hepatic lipid metabolism and [PMID:38306833] | Wen J, Sun H, Yang B, Song E, Song Y | Journal of hazardous materials | 2024 | 0 |
| A vision-based real-time traffic flow monitoring system for road intersections. [PMID:36789012] | ["Azimjonov J", "\u00d6zmen A", "Varan M | Multimedia tools and applicati | 2023 | 0 |
| Apolipoprotein E in lipid metabolism and neurodegenerative disease. [PMID:37357100] | Yang LG, March ZM, Stephenson RA, Naraya | Trends in endocrinology and me | 2023 | 0 |
| Controlled synthesis of silver-based ternary quantum dots with outstanding lumin [PMID:35678901] | ["Mbaz G", "Parani S", "Oluwafemi O"] | Journal of fluorescence | 2022 | 0 |
| Population Genomics of Plant Viruses: The Ecology and Evolution of Virus Emergen [PMID:33210987] | ["McLeish M", "Fraile A", "Garc\u00eda-A | Phytopathology | 2021 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.43 · 2026-04-20
closed · Rounds: 4 · Score: 0.89 · 2026-04-06
closed · Rounds: 4 · Score: 0.95 · 2026-04-01
Hypotheses and analyses mentioning domain_interaction in their description or question text
No additional research found