protein

UBE2B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UBE2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Debates

Summary

Page for UBE2B Protein

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🔬 Protein Info

Gene Symbol	UBE2B
Aliases	Page for UBE2B
Chromosome	5q31.1
Protein Type	Enzyme
Function	In neurons, proper UPS function is critical due to the post-mitotic nature of these cells, which cannot rely on cell division to eliminate damaged proteins.
Primary Expression	testis and is essential for male fertility
Molecular Weight	17 kDa
Pathways	cascade: E1-E2-E3 Cascade:
UniProt ID	P62256
NCBI Gene ID	7329
Ensembl ID	ENSG00000119009
OMIM	604385
GeneCards	UBE2B
Human Protein Atlas	UBE2B
Translesion Synthesis	UBE2B-mediated PCNA ubiquitination allows DNA polymerases to bypass DNA lesions that would otherwise block replication [3].
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: UBE2B — AlphaFold P62256 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

UBE2B - Gene

gene · 900 words

→

UBE2B Protein

protein · 837 words

→

Pathway Diagram

graph TD
    UBE2B["UBE2B"]
    neurodegeneration["neurodegeneration"]
    UBE2B -->|"implicated_in"| neurodegeneration
    style UBE2B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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No outgoing edges

Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning UBE2B in their description or question text

No additional research found