Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about UBXD3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | UBXD3 |
| Full Name | UBX Domain Containing 3 |
| Chromosome | 13q14.2 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | Ubiquitous, brain enriched |
| Amino Acids | 372 aa |
| Exons | 9 |
| UniProt ID | [Q9H6X7](https://www.uniprot.org/uniprot/Q9H6X7) |
| Ensembl ID | ENSG00000125124 |
| GeneCards | UBXD3 |
| Human Protein Atlas | UBXD3 |
| N-terminal Region | Contains potential regulatory sequences including serine/threonine phosphorylation sites |
| Coiled-coil Regions | Mediate homodimerization or heterodimerization with other UBX proteins |
| ER-associated Degradation (ERAD) | UBXD3 interfaces with the VCP/p97 complex to extract misfolded proteins from the endoplasmic reticulum for proteasomal degradation |
| Ubiquitin-Proteasome System | Acts as a co-factor for VCP/p97-mediated protein extraction and degradation |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
UBXD3["UBXD3"]
neurodegeneration["neurodegeneration"]
UBXD3 -->|"implicated_in"| neurodegeneration
style UBXD3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning UBXD3 in their description or question text
No additional research found