Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VPS54: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Vacuolar Protein Sorting 54 - a key component of endolysosomal trafficking machinery involved in ALS and hereditary spastic paraplegia.
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| Gene Symbol | VPS54 |
| Full Name | Vacuolar Protein Sorting 54 |
| Chromosome | 2p21 |
| Function | is a key component of the vacuolar protein sorting machinery that plays critical roles in endolysosomal trafficking. |
| Molecular Weight | 110 kDa |
| Amino Acids | 972 aa |
| Exons | 20 coding exons |
| UniProt ID | Q9P1C0 |
| NCBI Gene ID | 51542 |
| Ensembl ID | ENSG00000143952 |
| OMIM | 610412 |
| GeneCards | VPS54 |
| Human Protein Atlas | VPS54 |
| Associated Diseases | ALS, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
A["Upstream Regulators"] --> B["VPS54"]
B --> C["Molecular Mechanism"]
C --> D["Cellular Effects"]
D --> E["Pathological Consequences"]| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning VPS54 in their description or question text
No additional research found