gene

VRK1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about VRK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

VRK1 — Vaccinia-Related Kinase 1

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🧬 Gene Info

Gene Symbol	VRK1
Full Name	Vaccinia-Related Kinase 1
Chromosome	14q32.33
Protein Type	Kinase
Function	VRK1 encodes a serine/threonine protein kinase belonging to the VRK (Vaccinia-Related Kinase) family.
UniProt ID	Q15818
NCBI Gene ID	7443
Ensembl ID	ENSG00000100749
OMIM	604680
GeneCards	VRK1
Human Protein Atlas	VRK1
Cell cycle regulation	VRK1 phosphorylates p53, Thr-18, which disrupts p53-MDM2 interaction
DNA damage response	phosphorylates CHK2 and ATM/ATR substrates
Chromatin condensation	VRK1 phosphorylates histone H3 (Ser-10) and BAF (barrier-to-autointegration factor)
Neuronal development	regulates neurite outgrowth and neuronal differentiation
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VRK1 — AlphaFold Q15818 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

VRK1 — Vaccinia-Related Kinase 1

gene · 605 words

→

VRK1 Protein — Vaccinia-Related Kinase 1

protein · 585 words

→

Pathway Diagram

graph TD
    VRK1["VRK1"]
    neurodegeneration["neurodegeneration"]
    VRK1 -->|"implicated_in"| neurodegeneration
    style VRK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning VRK1 in their description or question text

No additional research found