gene

WDR45L

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about WDR45L: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

WDR45L Gene

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🧬 Gene Info

Gene Symbol	WDR45L
Full Name	WD Repeat Domain 45 Like
Chromosome	5q13.2
Function	WDR45L is a WD40 repeat protein that functions in the autophagy pathway, specifically in the formation of autophagosomes from omegasomes
UniProt ID	[Q5JWC1](https://www.uniprot.org/uniprot/Q5JWC1)
Ensembl ID	ENSG00000147065
GeneCards	WDR45L
Human Protein Atlas	WDR45L
WD40 repeats	Seven WD40 repeat domains that form a beta-propeller structure
PI3P-binding site	Mediates recruitment to PI3P-rich membranes
ATG2A/B binding region	Interacts with ATG2 proteins for lipid transfer
Selective autophagy	Involved in mitophagy and pexophagy
ER-phagy	Regulates ER turnover via ER-phagy
Lipid droplet autophagy	Participates in lipophagy
Phenotype	Childhood static encephalopathy with adult-onset neurodegeneration
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

WDR45L Gene

gene · 710 words

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Pathway Diagram

graph TD
    WDR45L["WDR45L"]
    neurodegeneration["neurodegeneration"]
    WDR45L -->|"implicated_in"| neurodegeneration
    style WDR45L fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning WDR45L in their description or question text

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