XK

Understanding Entity Pages

This page aggregates everything SciDEX knows about XK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

XK encodes a membrane protein forming the Kell blood group system precursor, crucial for neuronal health. Mutations cause McLeod syndrome, a Huntington's disease phenocopy.

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graph TD
    XK["<b>XK</b>"]
    VPS13A["VPS13A"]
    XK -->|"interacts with"| VPS13A
    phosphatidylserine["phosphatidylserine"]
    XK -->|"regulates"| phosphatidylserine
    McLeod_syndrome{"McLeod_syndrome"}
    XK -->|"causes"| McLeod_syndrome
    neurodegeneration{"neurodegeneration"}
    XK -->|"associated with"| neurodegeneration
    acanthocytes["acanthocytes"]
    XK -->|"associated with"| acanthocytes
    basal_ganglia["basal_ganglia"]
    XK -->|"associated with"| basal_ganglia
    lipid_processing["lipid_processing"]
    XK -->|"participates in"| lipid_processing
    lipid_trafficking["lipid_trafficking"]
    XK -->|"participates in"| lipid_trafficking
    XK -->|"implicated in"| neurodegeneration
    style XK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

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