Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VPS13A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | VPS13A |
| Full Name | Vacuolar Protein Sorting 13 Homolog A |
| Chromosome | 9q21.13 |
| Function | VPS13A encodes a member of the vacuolar protein sorting 13 (VPS13) family of proteins, which are involved in membrane trafficking between organelles. |
| Primary Expression | the brain, with high expression in the basal ganglia (caudate nucleus, putamen), cerebral cortex, and cerebellum |
| Molecular Weight | 350 kDa |
| Amino Acids | 3179 aa |
| UniProt ID | Q9UPQ3 |
| NCBI Gene ID | 23286 |
| Ensembl ID | ENSG00000140320 |
| OMIM | 216950 |
| GeneCards | VPS13A |
| Human Protein Atlas | VPS13A |
| VPS13B, VPS13C, VPS13D | Related lipid transport proteins with distinct tissue distributions and roles in Cohen syndrome and other lipid storage disorders |
| ERMES Complex | ER-mitochondrial encounter structure components that functionally interact with VPS13A |
| Associated Diseases | Huntington's disease, neurodegeneration |
| Interactions | XK |
| KG Connections | 6 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["VPS13A"]
N1["XK"]
N1 -->|"interacts with"| N0
N2["neurodegeneration"]
N0 -->|"implicated in"| N2
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 gene| Target | Relation | Type | Str |
|---|---|---|---|
| ferroptosis | participates_in | pathway | 0.60 |
| neurodegeneration | causes | disease | 0.60 |
| Huntington's disease | causes | disease | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||