Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about XLF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | XLF |
| Function | is a human gene whose product xLF (also known as NHEJ factor X or Cernunnos) is a core DNA non-homologous end joining (NHEJ) repair protein essential for V(D)J recombination and DSB repair[@ahnesor... |
| GeneCards | XLF |
| Human Protein Atlas | XLF |
| DNA end bridging | XLF homodimers tether blunt DNA ends together[@li2008] |
| V(D)J recombination | Essential for antigen receptor gene rearrangement in lymphocytes[@callebaut2006] |
| XRCC4-LIG4 recruitment | Directs ligase IV complex to DNA ends[@hentges2006] |
| Loop formation | Generates DNA loop structures facilitating repair[@lu2007] |
| SCID with microcephaly | Biallelic XLF mutations cause severe combined immunodeficiency with growth retardation[@buck2006] |
| radiosensitive SCID | Cellular sensitivity to ionizing radiation[@du2008] |
| Lymphoma | XLF variants in some B-cell malignancies[@liu2012] |
| Solid tumors | Altered expression in various cancers[@saito2011] |
| Alzheimer's disease | NHEJ components dysregulated in AD neurons; impaired DSB repair[@madsen2011] |
| Ataxia-telangiectasia | Overlapping phenotype with ATM deficiency[@stewart2009] |
| Cancer therapy | XLF as target for radiosensitization[@neal2015] |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
XLF["XLF"]
neurodegeneration["neurodegeneration"]
XLF -->|"implicated_in"| neurodegeneration
style XLF fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity