Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about amyloid_clearance: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
A mechanism referenced in 2 knowledge graph relationships. Key connections: phagocytosis (mechanism) promotes; protective_against alzheimers (disease).
| Name | amyloid_clearance |
| Key Genes/Proteins | apolipoprotein_E, ACE |
| Linked Hypotheses | 4 hypotheses |
Knowledge base pages for this entity
graph TD
amyloid_clearance["amyloid_clearance"]
apolipoprotein_E("apolipoprotein_E")
apolipoprotein_E -->|"regulates"| amyloid_clearance
APOE4_domain_interaction["APOE4_domain_interaction"]
APOE4_domain_interaction -->|"impairs"| amyloid_clearance
ACE["ACE"]
ACE -->|"enhances"| amyloid_clearance| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| apolipoprotein_E | regulates | protein | 0.80 |
| APOE4_domain_interaction | impairs | structural_defect | 0.80 |
| microglia | performs | cell_type | 0.70 |
| ACE | enhances | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from | 0.588 | neurodegeneration | How does APOE4's beneficial immune funct |
| Test: TREM2 enhances amyloid clearance | 0.405 | - | - |
| Microglial ACE Enhancement for Amyloid Clearance | 0.399 | neurodegeneration | Gene expression changes in aging mouse b |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.444
neurodegeneration | 2026-04-12 | 0 hypotheses
synaptic biology | 2026-04-07 | 0 hypotheses
neurodegeneration | 2026-04-03 | 34 hypotheses Top: 0.692
neurodegeneration | 2026-04-03 | 17 hypotheses Top: 0.662
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Hippocampal Atrophy on Magnetic Resonance Imaging as a Surrogate Marker for Clin [PMID:41324786] | Abushakra S, Doraiswamy PM, Hey JA, Tosu | CNS drugs | 2026 | 0 |
| Adverse childhood experiences and cardiometabolic risk factors in people with bi [PMID:40935250] | Turner A, Kuperberg M, McGovern H, Wrobe | J Affect Disord | 2026 | 0 |
| Indole-3-propionic acid links gut dysfunction to diabetic retinopathy: a biomark [PMID:41198173] | Prasad R, Adu-Rutledge Y, Ziani B, Floyd | Gut | 2026 | 0 |
| Amyloidosis of bridging veins is a pathologic feature of Alzheimer's disease. [PMID:41329157] | Smyth LCD, Verhaege D, Standen-Bloom E, | J Exp Med | 2026 | 0 |
| A minimally invasive dried blood spot biomarker test for the detection of Alzhei [PMID:41491101] | Huber H, Montoliu-Gaya L, Brum WS, Vávra | Nat Med | 2026 | 0 |
| [Polypharmacy and nephrotoxicity]. [PMID:41535444] | Czock D, Ebinger K, Sommerer C | Inn Med (Heidelb) | 2026 | 0 |
| Association between sleep duration and fluid biomarkers of Alzheimer's disease: [PMID:41610733] | Young VM, Zeynoun J, Ruiz Laza A, Salard | Sleep Med Rev | 2026 | 0 |
| Long-term amyloid PET and MRI outcomes in a menopausal hormone therapy trial. [PMID:41618732] | Kantarci K, Kara F, Tosakulwong N, Fough | Alzheimers Dement | 2026 | 0 |
| Plasma ATN biomarkers across the alzheimer's disease continuum in a Chilean comm [PMID:41691306] | Orellana P, Henríquez F, Cabral-Miranda | Alzheimers Res Ther | 2026 | 0 |
| Neuro-renin-angiotensin-aldosterone system axis in alzheimer's disease: from mol [PMID:41706377] | Singh G, Maparu K, Aran KR | Metab Brain Dis | 2026 | 0 |
| Renin-angiotensin system blockade attenuates brain mitochondrial dysfunction, ox [PMID:41883437] | García Menéndez S, Inserra F, de Cavanag | World J Exp Med | 2026 | 0 |
| Association Between ACE (I/D) Polymorphism and Essential Hypertension (EH): An U [PMID:41899774] | Smallwood A, Akam E, Hunter DJ, Singh M, | Int J Environ Res Public Healt | 2026 | 0 |
| Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD (WARRIOR): a rand [PMID:41932694] | Pepine CJ, Handberg E, Cooper-DeHoff R, | Open Heart | 2026 | 0 |
| Renin-Angiotensin-Aldosterone Medication Use and Outcomes in Injured Patients Re [PMID:41936145] | Werenski HE, Diz DI, Chappell MC, Hoth J | J Surg Res | 2026 | 0 |
| Characteristics of reproductive tract microbiota in health and disease. [PMID:41936969] | Han Q, Wang N, Feng T, Li YY, Zhu Z et a | Microb Pathog | 2026 | 0 |
| Novel_circ_002651 regulates the immune defense of eastern honeybee larvae agains [PMID:41940497] | Zhang K, Wang F, Fan N, Fan X, Wu T et a | Virulence | 2026 | 0 |
| Safety and tolerability of the ACE-inhibitor lisinopril among Nigerian adults wi [PMID:41945136] | Dankishiya FS, Muhammad H, Wudil UJ, Mus | Naunyn Schmiedebergs Arch Phar | 2026 | 0 |
| Ace in the hole: playing cards show the role of order and magnitude in the SNARC [PMID:41945148] | Mingolo S, Prpic V, Cipora K, Bilotta E, | Psychol Res | 2026 | 0 |
| Feasibility of implementing an auditory rehabilitation program for older adults [PMID:41945417] | Torrente MC, Vasquez C, Bravo R, Miranda | Acta Otolaryngol | 2026 | 0 |
| Spatial distribution and health risk assessment of heavy metals in soils around [PMID:41954659] | Tengbeh AS, Akande IO, Offor CC, Abdulai | Environ Geochem Health | 2026 | 0 |