gene

ACE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

360Connections

16Hypotheses

22Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	ACE
Full Name	Angiotensin-Converting Enzyme
Aliases	ACE1, CD143, DCP1
Chromosome	17q23.3
Protein Type	Protease
Function	Converts angiotensin I to angiotensin II
Molecular Weight	149.7 kDa
Amino Acids	1306
Pathways	Renin-angiotensin system, Bradykinin metabolism
UniProt ID	P12821
NCBI Gene ID	1636
Ensembl ID	ENSG00000159640
OMIM	106180
GeneCards	ACE
Human Protein Atlas	ACE
Associated Diseases	ALS, Alzheimer, Alzheimer's disease, Cardiac, Depression
Interactions	TNF, STAT1, EGFR, NUP98, UBIQUITIN, TAU
SciDEX Hypotheses	Microglial ACE Enhancement for Amyloid Clearance
KG Connections	360 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure: ACE — PDB 1O86 Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ACE["ACE"] -->|"associated"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ACE["ACE"] -.->|"inhibits"| Hypertension["Hypertension"]
    style Hypertension fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ACE["ACE"] -.->|"inhibits"| Oxidative_Stress["Oxidative Stress"]
    style Oxidative_Stress fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#e0e0e0
    ACE["ACE"] -->|"associated"| GENES["GENES"]
    style GENES fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    ACE["ACE"] -->|"associated"| APOE["APOE"]
    style APOE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    ACE["ACE"] -->|"associated"| Ms["Ms"]
    style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ACE["ACE"] -->|"therapeutic target"| Alzheimer["Alzheimer"]
    style Alzheimer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -.->|"inhibits"| ACE["ACE"]
    style OXIDATIVE_STRESS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    GENES_1["GENES"] -->|"associated"| ACE["ACE"]
    style GENES_1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    APOPTOSIS["APOPTOSIS"] -.->|"inhibits"| ACE["ACE"]
    style APOPTOSIS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    TAU["TAU"] -->|"associated"| ACE["ACE"]
    style TAU fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    CLU["CLU"] -->|"associated"| ACE["ACE"]
    style CLU fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style ACE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (266)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
Interleukin-18	interacts_with	protein	0.80
Als	associated_with	disease	0.75
Hypertension	inhibits	disease	0.75
APOE	associated_with	gene	0.70
Oxidative Stress	inhibits	pathway	0.70
GENES	associated_with	gene	0.70
Ms	associated_with	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Alzheimer	expressed_in	disease	0.65
ALS	associated_with	disease	0.65
Cardiac	implicated_in	disease	0.65
Als	inhibits	disease	0.65
Sepsis	activates	disease	0.65
Aging	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Heart Failure	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Cardiac	inhibits	disease	0.65
Type 2 Diabetes	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Diabetes	inhibits	disease	0.65
Stroke	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Cancer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Schizophrenia	associated_with	disease	0.65
Neurodegeneration	degrades	disease	0.65
Cancer	degrades	disease	0.65
Vascular Dementia	transports	disease	0.65
Alzheimer	transports	disease	0.65
Dementia	transports	disease	0.65
ALS	transports	disease	0.65
Frontotemporal Dementia	transports	disease	0.65
Frontotemporal Dementia	therapeutic_target	disease	0.65
Vascular Dementia	therapeutic_target	disease	0.65
TNF	activates	gene	0.60
TREM2	therapeutic_target	gene	0.60
PILRA	therapeutic_target	gene	0.60
IDUA	therapeutic_target	gene	0.60
TAU	therapeutic_target	gene	0.60
GRN	therapeutic_target	gene	0.60

Incoming (94)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
h-1e28311b	targets_gene	hypothesis	0.90
OXIDATIVE STRESS	inhibits	gene	0.70
TAU	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CR1	associated_with	gene	0.60
PON1	associated_with	gene	0.60
SRC	inhibits	gene	0.60
CTSH	associated_with	gene	0.60
PTK2B	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
APOE	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
ABCA1	associated_with	gene	0.60
LILRB2	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
CD33	associated_with	gene	0.60
LRP1	activates	gene	0.60
CLU	expressed_in	gene	0.60
SPG7	expressed_in	gene	0.60
MAPT	expressed_in	gene	0.60
LDLR	expressed_in	gene	0.60
SORL1	associated_with	gene	0.60
IL1A	associated_with	gene	0.60
IL10	associated_with	gene	0.60
PLAU	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
MAPT	associated_with	gene	0.60
IL6	associated_with	gene	0.60
CHAT	therapeutic_target	gene	0.60
CYP3A4	therapeutic_target	gene	0.60
APOE	therapeutic_target	gene	0.60
CYP2D6	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
NUP98	activates	gene	0.60
TGFB1	associated_with	gene	0.60
PRNP	associated_with	gene	0.60
IDE	associated_with	gene	0.60
HSPG2	associated_with	gene	0.60
PPAR	transports	gene	0.60
APOE	transports	gene	0.60
ABCB1	transports	gene	0.60
CHAT	transports	gene	0.60
HCRTR2	associated_with	gene	0.60
HCRTR1	associated_with	gene	0.60
SPI1	associated_with	gene	0.60
APP	associated_with	gene	0.60
NDUFS8	expressed_in	gene	0.60
PLCG2	associated_with	gene	0.60

Targeting Hypotheses (16)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
IL-6 Trans-Signaling Blockade at the Oligodendrocyte-Microgl	0.632	neuroinflammation	How do oligodendrocytes initiate neuroin
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode
Vicious Cycle Hypothesis: Cholinergic Dysfunction Exacerbate	0.610	-	Do β-amyloid plaques and neurofibrillary
HDAC6 Selective Inhibition to Restore Acetylation Balance an	0.577	structural biology	What is the atomic-resolution structure
Vascular-Glial Interface Restoration	0.544	neurodegeneration	Cell type vulnerability in Alzheimers Di

SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso	0.542	neurodegeneration	What molecular mechanisms link elevated
BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imb	0.527	neurodegeneration	What are the physiological functions of
Vascular mural cell degeneration precedes and exacerbates pa	0.520	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK	0.509	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammatio	0.486	translational neuroscience	Which metabolic biomarkers can distingui
Extracellular Matrix Stiffness Modulation	0.427	neurodegeneration	Microglia-astrocyte crosstalk amplificat
RAB27A-dependent extracellular vesicle engineering for mitoc	0.414	neurodegeneration	Mitochondrial transfer between astrocyte
Palmitoylation-Targeted BACE1 Trafficking Disruptors	0.407	neurodegeneration	Lipid raft composition changes in synapt
Microglial ACE Enhancement for Amyloid Clearance	0.399	neurodegeneration	Gene expression changes in aging mouse b
Microglia-Derived Extracellular Vesicle Engineering for Targ	0.370	neurodegeneration	Mitochondrial transfer between neurons a
Extracellular Vesicle Biogenesis Modulation	0.340	Alzheimer's Disease	Tau propagation mechanisms and therapeut

Mentioning Analyses (22)

Scientific analyses that reference this entity

What are the physiological functions of BACE1 beyond APP processing that could c

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.527

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.586

Does clusterin exacerbate or protect against neuronal death in neurodegeneration

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.548

Why do p300/CBP inhibitors reduce both AD incidence and clinically diagnosed TBI

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.604

Does TRT-induced erythrocytosis actually increase venous thromboembolism risk in

endocrinology | 2026-04-13 | 2 hypotheses Top: 0.572

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosoma [PMID:41778730]	Zhang Y, Jiang H, Zhang F, Liao J	Neural regeneration research	2026
The myocardial ischemic cascade network and multi-target synergistic interventio [PMID:41544859]	Qi L, Yi J, Shen Y, Jiang H, Yao X et al	Biochem Pharmacol	2026
Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004]	Zhang H, Xiao J, Yi Y, Chen B, Lv W et a	Phytomedicine	2026
Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005]	You T, Dai B, Ding X, He Z, Peng J et al	Phytomedicine	2026
AARS2 R199C mutation induces lactylation-driven premature ovarian insufficiency [PMID:41832996]	Zhang HH, Zhang ZL, Xu W	Reproduction	2026
Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969]	Wang Y, Yuan Q	Clin Exp Pharmacol Physiol	2026
FGFR1 suppresses ovarian cancer progression by modulating SIRT3-dependent lactyl [PMID:41946672]	Jiang F, Huang H, Dong Z, Zhang L, Zhang	Cell Death Discov	2026
Adipocyte small extracellular vesicle-derived microRNA-30a-3p exacerbates hepati [PMID:41965824]	Zhang T, Hu L, Chen D, Chen Y, Zhou F et	Nat Commun	2026
α7-nAChR activation mitigates pyridaben-induced hepatotoxicity in grass carp (Ct [PMID:41966317]	Wu C, Jiang J, Qiu H, Xie J, Li S	Fish Shellfish Immunol	2026
Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated [PMID:41896899]	Fang Y, Deng M, Huang K, Song H, Chu Y,	Cell communication and signali	2026
Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via P [PMID:41906653]	Xu Z, Cui X, Chu H, Wan H, Xie Y, Wang Y	Journal of diabetes	2026
Inhibition of mitochondrial ROS turns LC3-associated phagocytosis to autophagy u [PMID:41896101]	Cheng YL, Su MS, Liao CC, Chang TW, Hsie	Journal of microbiology, immun	2026
Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney [PMID:41903436]	Shan C, Szili-Torok T, Yue G, Zhang L, M	Phytomedicine : international	2026
Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promotin [PMID:41897550]	["Gao L", "Shen J", "Gao J", "Li T", "Ya	Antioxidants (Basel, Switzerla	2026
Pathophysiology of Primary Familial Brain Calcification. [PMID:41212990]	Keller A	Annual review of physiology	2026
Therapeutic effects of the n-butanol extract of Potentilla freyniana Bornm. in h [PMID:40902811]	Wang Y, Zhang Z, Cao L, Huang S, Huang X	J Ethnopharmacol	2026
Based on network pharmacology and experiments to investigate the inhibitory effe [PMID:41308710]	Yang X, Xiao JH, Li X, Liu RM, Yuan Q	J Ethnopharmacol	2026
Novel insights into meningioma brain invasion with spatial transcriptomic profil [PMID:41486296]	Maier AD, Laurentiussen CO, Michaelsen S	Acta Neuropathol Commun	2026
Brain vascular stability relies on PAK2-cilia-PDGF-BB-HSPGs on basolateral side [PMID:41490797]	Prabhudesai S, Thirugnanam K, Song X, Ya	Life Sci Alliance	2026
Plasma platelet-derived growth factor receptor-β decrease correlates with blood- [PMID:41530860]	Li J, Li A, Ye C, Zhang L, Jiang M et al	Mol Neurodegener	2026

ACE

Understanding Entity Pages

Wiki Pages (21)

ACE Gene

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Pathway Diagram

Outgoing (266)

Incoming (94)

Targeting Hypotheses (16)

Mentioning Analyses (22)

What are the physiological functions of BACE1 beyond APP processing that could c

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

Does clusterin exacerbate or protect against neuronal death in neurodegeneration

Why do p300/CBP inhibitors reduce both AD incidence and clinically diagnosed TBI

Does TRT-induced erythrocytosis actually increase venous thromboembolism risk in

How does HDAC1/2 deletion specifically enhance microglial amyloid phagocytosis c

Which tau PTMs are both disease-specific and druggable with selective small mole

What is the atomic-resolution structure of K280-acetylated tau and how does it t

Does reduced Prevotellaceae abundance cause PD pathology or result from it?

Do tau-containing vesicles exhibit unique surface glycosylation patterns that di

Which tau propagation mechanism predominates in different brain regions and dise

Trans-synaptic tau spreading and propagation mechanisms in AD

Tau propagation mechanisms and therapeutic interception points

Systemic immune profiling and peripheral immune contributions to neurodegenerati

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Tau propagation mechanisms and therapeutic interception points

Extracellular vesicle biomarkers for early AD detection

Tau propagation mechanisms and therapeutic interception points

Tau propagation mechanisms and therapeutic interception points

Perivascular spaces and glymphatic clearance failure in AD

Perivascular spaces and glymphatic clearance failure in AD

Related Papers (20)

ACE

Understanding Entity Pages

Wiki Pages (21)

ACE Gene

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Neurons — Cell Type Hierarchy

Alzheimer's Disease

Microglial Cells — Cell Type Hierarchy

ncam2

dendritic-spines

omega-3-fatty-acids-neurodegeneration

AI and Machine Learning in Neurodegeneration

Vascular Cognitive Impairment (VCI)

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

lithium-tauopathy

A Phase 3, Randomised, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy, Tolerability, and Safety of Combined Metabolic Activator Supplementation in Subjects Diagnosed With Alzheimer's Disease

PMN310 Anti-Amyloid for AD (NCT06750432)

Clinical Trials Dashboard

Section 147: Telehealth and Remote Monitoring in CBS/PSP

Traumatic Brain Injury and Neurodegeneration Pathway

Pathway Diagram

Outgoing (266)

Incoming (94)

Targeting Hypotheses (16)

Mentioning Analyses (22)

What are the physiological functions of BACE1 beyond APP processing that could c

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

Does clusterin exacerbate or protect against neuronal death in neurodegeneration

Why do p300/CBP inhibitors reduce both AD incidence and clinically diagnosed TBI

Does TRT-induced erythrocytosis actually increase venous thromboembolism risk in

How does HDAC1/2 deletion specifically enhance microglial amyloid phagocytosis c

Which tau PTMs are both disease-specific and druggable with selective small mole

What is the atomic-resolution structure of K280-acetylated tau and how does it t

Does reduced Prevotellaceae abundance cause PD pathology or result from it?

Do tau-containing vesicles exhibit unique surface glycosylation patterns that di

Which tau propagation mechanism predominates in different brain regions and dise

Trans-synaptic tau spreading and propagation mechanisms in AD

Tau propagation mechanisms and therapeutic interception points

Systemic immune profiling and peripheral immune contributions to neurodegenerati

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Tau propagation mechanisms and therapeutic interception points

Extracellular vesicle biomarkers for early AD detection

Tau propagation mechanisms and therapeutic interception points

Tau propagation mechanisms and therapeutic interception points

Perivascular spaces and glymphatic clearance failure in AD

Perivascular spaces and glymphatic clearance failure in AD

Related Papers (20)