Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about astrocyte network: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Glaucoma | therapeutic_target | disease | 0.90 |
| metabolite distribution | contributes_to | process | 0.85 |
| extracellular ionic buffering | contributes_to | process | 0.85 |
| optic neuropathy | therapeutic_target | disease | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GJA1 | involved_in | gene | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2-Mediated Senescent Microglial Reprogramming of Astrocy | 0.380 | neurodegeneration | Spatial Transcriptomics Analysis of Alzh |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Disentangling causality in brain aging: The complex interplay between glial sene [PMID:41871753] | Unknown | Exp Neurol | 2026 | 0 |
| Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's [PMID:38637622] | Rachmian N, Medina S, Cherqui U, Akiva H | Nat Neurosci | 2024 | 0 |
| Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's [PMID:38637622] | Rachmian N, Medina S, Cherqui U, Akiva H | Nature neuroscience | 2024 | 0 |
| Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's [PMID:38637622] | Unknown | Nature neuroscience | 2024 | 0 |
| Cellular senescence and neurodegeneration [PMID:34043900] | Martínez-Cué C, Rueda N | Frontiers in Cellular Neurosci | 2021 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning astrocyte network in their description or question text
No additional research found