GJA1

Understanding Entity Pages

This page aggregates everything SciDEX knows about GJA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

GJA1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, activates. Associated with ALS, Als, Alzheimer. Connected to 145 entities in the SciDEX knowledge graph.

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flowchart TD
    GJA1["GJA1<br/>(Connexin-43)"]
    
    %% Autophagy and protein degradation pathways
    GJA1 --|"regulates"|--> AUTOPHAGY["Autophagy<br/>Pathway"]
    GJA1 --|"regulates"|--> UPS["Ubiquitin-Proteasome<br/>System"]
    GJA1 --|"regulates"|--> LAMP1["LAMP1<br/>(Lysosomal marker)"]
    GJA1 --|"regulates"|--> SQSTM1["SQSTM1/p62<br/>(Autophagy receptor)"]
    
    %% Cytoskeletal regulation
    GJA1 --|"regulates"|--> VIM["VIM<br/>(Vimentin)"]
    GJA1 --|"regulates"|--> HDAC6["HDAC6<br/>(Cytoskeletal regulator)"]
    GJA1 --|"associated_with"|--> CDC42["CDC42<br/>(Cytoskeletal dynamics)"]
    
    %% Cellular stress responses
    GJA1 --|"activates"|--> OXSTRESS["Oxidative Stress<br/>Response"]
    GJA1 --|"protects_against"|--> DRP1["DRP1<br/>(Mitochondrial fission)"]
    GJA1 --|"associated_with"|--> CASP3["CASP3<br/>(Apoptosis executor)"]
    
    %% Cellular processes
    GJA1 --|"activates"|--> EXOCYTOSIS["Exocytosis<br/>Pathway"]
    
    %% Disease associations
    GJA1 --|"therapeutic_target"|--> MS["Multiple Sclerosis<br/>(MS)"]
    GJA1 --|"expressed_in"|--> ALS["Amyotrophic Lateral<br/>Sclerosis (ALS)"]
    
    %% Pathway outcomes
    AUTOPHAGY --> NEUROPROT["Neuroprotection"]
    UPS --> PROTEINHOM["Protein<br/>Homeostasis"]
    OXSTRESS --> NEURODEGEN["Neurodegeneration"]
    CASP3 --> CELLDEATH["Cell Death"]
    
    %% Styling
    style GJA1 fill:#006494
    style AUTOPHAGY fill:#1b5e20
    style UPS fill:#1b5e20
    style NEUROPROT fill:#1b5e20
    style PROTEINHOM fill:#1b5e20
    style OXSTRESS fill:#ef5350
    style NEURODEGEN fill:#ef5350
    style CELLDEATH fill:#ef5350
    style LAMP1 fill:#4a1a6b
    style SQSTM1 fill:#4a1a6b
    style HDAC6 fill:#4a1a6b
    style DRP1 fill:#4a1a6b
    style MS fill:#5d4400
    style ALS fill:#5d4400