Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about autophagy enhancement: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| APOE4-mediated tau pathology | prevents | phenotype | 0.70 |
| APOE4-mediated tau pathology | prevents | phenotype | 0.70 |
| Tau Clearance | associated_with | phenotype | 0.70 |
| Senescent Cell Clearance | associated_with | phenotype | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| mTOR inhibition | activates | drug | 0.70 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.644
neurodegeneration | 2026-04-08 | 7 hypotheses Top: 0.390
neurodegeneration | 2026-04-03 | 6 hypotheses
neurodegeneration | 2026-04-01 | 15 hypotheses Top: 0.822
neurodegeneration | 2026-04-01 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Meta-analysis of LRP1 C766T polymorphism and Alzheimer's disease susce | exploratory | Alzheimer's disease | 0.950 | 0.00 | human patients | proposed | N/A |
| Autophagy receptor identification for stress granule elimination | exploratory | neurodegenerative diseases | 0.900 | 0.00 | cultured cells under arsenite | proposed | N/A |
| Endothelial CD2AP knockdown effects on memory in male mice | validation | Alzheimer's disease | 0.900 | 0.00 | male mice | proposed | N/A |
| Amyloid plaque load analysis in triple-mutant mouse brains | exploratory | Alzheimer's disease | 0.880 | 0.00 | APP/PSEN1/GD3S-/- triple-trans | proposed | N/A |
| Reelin treatment rescue via ApoER2 in CD2AP mutant mice | validation | Alzheimer's disease | 0.870 | 0.00 | mice | proposed | N/A |
| Network Pharmacology Analysis of Shared AD Targets | exploratory | Alzheimer's disease | 0.850 | 0.00 | Computational network analysis | proposed | N/A |
| MRI Phenotyping Method Concordance in Serbian AD Cohort | clinical | Alzheimer's disease | 0.850 | 0.00 | human patients | proposed | N/A |
| Endothelin-1 receptor A antagonist rescue in male CD2AP mice | validation | Alzheimer's disease | 0.850 | 0.00 | male mice | proposed | N/A |
| Endothelin-1 receptor A antagonist rescue experiment | validation | Alzheimer's disease | 0.850 | 0.00 | mice | proposed | N/A |
| Neuroimmune modulation and Aβ clearance mechanisms | exploratory | Alzheimer's disease | 0.820 | 0.00 | Microglia and astrocytes | proposed | N/A |
| Competing endogenous RNA (ceRNA) network construction | exploratory | Alzheimer's disease | 0.750 | 0.00 | computational network analysis | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020] | Chua JP, De Calbiac H, Kabashi E, Barmad | Autophagy | 2022 | 2 |
| Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury vi [PMID:41800257] | Jin X, Xue H, Shi X, Zhou Y, Zhang J, Ze | International journal of biolo | 2026 | 0 |
| TMEM259/MEMBRALIN is a non-canonical ER-phagy receptor that associates with MAN1 [PMID:41799849] | Camilleri JM, Zhang J, Wang T, Ahmad I, | Autophagy reports | 2026 | 0 |
| Evaluation of Copathology and Clinical Trajectories in Individuals With Tau-Clin [PMID:41396614] | Brown CA, Mundada NS, Cousins KAQ, Sadeg | JAMA neurology | 2026 | 0 |
| Membralin Assembles a MAN1B1-VCP Complex to Target Foreign Glycoproteins from th [PMID:41324484] | Zhang J, Lu X, Li S, Wang T, Ahmad I et | Adv Sci (Weinh) | 2026 | 0 |
| Viscum coloratum polysaccharide ameliorates hyperuricemic nephropathy by upregul [PMID:41325866] | Zhang K, Sun S, Qiu H, Zhao H, Zhao H et | J Ethnopharmacol | 2026 | 0 |
| Evaluation of Copathology and Clinical Trajectories in Individuals With Tau-Clin [PMID:41396614] | Brown CA, Mundada NS, Cousins KAQ, Sadeg | JAMA Neurol | 2026 | 0 |
| Aberrant nuclear pore complex degradation contributes to neurodegeneration in VC [PMID:41475349] | Dubey SK, Chaubey D, Ikenaga C, Lin WW, | Neuron | 2026 | 0 |
| Genetic commonalities between rare subtypes of ALS and CMT: insights into molecu [PMID:41621017] | Aynaashe A, Kursula P | Amino Acids | 2026 | 0 |
| Genetic Spectrum and Phenotypic Variability in Chinese Patients with Multisystem [PMID:41737544] | Xia X, Chen X, Sun Y, Zhang M, Qiao K et | Degener Neurol Neuromuscul Dis | 2026 | 0 |
| Study of Fecal Microbiota Transplantation Ameliorates Colon Morphology and Micro [PMID:41745910] | Cao X, Zhou L, Ding Y, Ma C, Chen Q et a | Vet Sci | 2026 | 0 |
| Effect of fermented grape pomace on growth performance and intestinal health of [PMID:41749330] | Wang M, Li Q, Guo A, Yue J, Zhang L et a | Anim Microbiome | 2026 | 0 |
| STUB1-VCP/p97 limits PINK1 overaccumulation to safeguard mitophagy and memory. [PMID:41964371] | Lin JY, Huang ZB, Fang EF, Lu G | Autophagy | 2026 | 0 |
| Clinical impact of the Alzheimer's Disease Neuroimaging Initiative: A review of [PMID:41988903] | Kanoria S, Veitch DP, Miller MJ, Aisen P | Alzheimers Dement | 2026 | 0 |
| Inhibition of PGK1 enhances sensitivity to tyrosine kinase inhibitor in T315I-mu [PMID:41909749] | Wang H, Jiang F, Pan A, Jin C, Xue Y, Li | Acta pharmaceutica Sinica. B | 2026 | 0 |
| Diagnostic performance of transcutaneous laryngeal ultrasound for vocal cord par [PMID:41134433] | Luo X, Xiong J, Liang S, Jiang Z, Chen H | Esophagus : official journal o | 2026 | 0 |
| The vital role of p97/valosin-containing protein-mediated degradation pathways i [PMID:41780115] | Phyu SM, Loh JXY, Zhao Y, Ramadan K | Current opinion in cell biolog | 2026 | 0 |
| Aberrant nuclear pore complex degradation contributes to neurodegeneration in VC [PMID:41475349] | Dubey SK, Chaubey D, Ikenaga C, Lin WW, | Neuron | 2026 | 0 |
| Genetic commonalities between rare subtypes of ALS and CMT: insights into molecu [PMID:41621017] | Aynaashe A, Kursula P | Amino acids | 2026 | 0 |
| STUB1-VCP/p97 complex regulates mitophagy via fine-tuning of PINK1 levels. [PMID:41903135] | Lin JY, Huang ZB, Zhang SQ, Wu Y, Cheng | Cell reports | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 4 · Score: 0.74 · 2026-04-16
closed · Rounds: 4 · Score: 0.94 · 2026-04-10
closed · Rounds: 4 · Score: 0.89 · 2026-04-06
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
closed · Rounds: 5 · Score: 0.94 · 2026-04-01
Hypotheses and analyses mentioning autophagy enhancement in their description or question text
Score: 0.380 · proteomics · 2026-04-27
This hypothesis proposes that TFEB activation serves as a therapeutic strategy for neurodegenerative diseases by enhanci
Score: 0.000 · unknown disease · 2026-04-28
TFEB activation could simultaneously restore GBA enzyme function and clear α-synuclein aggregates by enhancing lysosomal
Score: 0.000 · unknown disease · 2026-04-28
Sequential treatment with autophagy enhancers (rapamycin/spermidine) followed by senolytics will improve clearance of se
Score: 0.000 · unknown disease · 2026-04-28
Enhanced autophagy pathways to improve tau protein clearance, reframed from the clearance/aggregation trade-off hypothes
Score: 0.000 · unknown disease · 2026-04-28
Autophagy machinery genes (ATG family) may exhibit population-specific expression patterns in SEA-AD, potentially due to
Score: 0.000 · unknown disease · 2026-04-28
Boosting autophagy in oligodendrocytes to enhance clearance of damaged myelin debris and reduce neuroinflammation Debat
Score: 0.000 · unknown disease · 2026-04-28
Clear protein aggregates and damaged organelles in high-metabolic stellate neurons through enhanced autophagy, preventin