🧫
Neuroimmune modulation and Aβ clearance mechanisms
active
experiment
Created: 2026-04-10T22:46:49
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-09e8c128-8a21-4e7f-bc75-3a1ee037aafe
🧫 Experiment Protocol
ExploratoryAlzheimer's diseaseHDAC4, NHE6, LAMP2Microglia and astrocytesproposed
This experiment examined how the HDAC4-NHE6-pH axis modulates the neuroimmune microenvironment to enhance amyloid-β clearance through multiple synergistic mechanisms. The study investigated upregulation of phagocytic receptors and microglial recruitment for Aβ plaque phagocytosis. Additionally, it examined reactivation of autophagy-lysosomal function in astrocytes through increased LAMP2 expression. This comprehensive analysis demonstrated how pH regulation affects both microglial and astrocytic functions in Aβ clearance, providing evidence for the multifaceted therapeutic approach of targeting the HDAC4-NHE6 pathway.
PRIMARY OUTCOME
Enhanced Aβ clearance through neuroimmune modulation
EXPECTED OUTCOMES
Upregulated phagocytic receptors, increased microglial Aβ phagocytosis, enhanced astrocytic autophagy-lysosomal function
SUCCESS CRITERIA
Increased phagocytic receptor expression, enhanced microglial recruitment and Aβ uptake, elevated LAMP2 expression and improved autophagy-lysosomal function
PROTOCOL
Assessment of phagocytic receptor expression, microglial recruitment assays, measurement of LAMP2 expression, evaluation of autophagy-lysosomal function in astrocytes
LINKED HYPOTHESES
Source: PMID 41933339 ↗
🧫 Experiment Extras
PATHWAY
Autophagy-lysosomal pathway, microglial phagocytosis, astrocytic clearance mechanisms
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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