cell 866 words KG: ent-gene-fb955035
Contents

Neurotensin Receptor 1 Neurons

🔬 Protein Info
Gene Symbolent-gene-fb955035
Substantia NigraHigh density in pars compacta (SNC) and pars reticulata (SNR)
Ventral Tegmental Area (VTA)Abundant expression in dopaminergic cell groups
HypothalamusStrong expression in preoptic, supraoptic, and paraventricular nuclei
CortexLayer-specific expression, particularly in layer V pyramidal neurons
AmygdalaModerate to high expression in central and medial nuclei
Raphe NucleiSerotonergic neurons co-expressing NTSR1
SomaticStrong expression on cell bodies of dopaminergic and GABAergic neurons
DendriticPostsynaptic localization for receiving neurotensin inputs
AxonalPresynaptic expression on terminals for neurotransmitter modulation
N-terminal extracellular domainContains neurotensin binding site
Seven transmembrane domainsClassic GPCR architecture
C-terminal intracellular domainCouples to G proteins and contains phosphorylation sites
Dimerization interfaceCan form homodimers and heterodimers
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (7)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.88
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53
...
Score: 0.68

Related Analyses (12)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Knowledge Graph (2 edges)

ent-gene-fb955035 data_in benchmark_ot_ad_answer_key:NTSR1
benchmark_ot_ad_answer_key:NTSR1 data_in ent-gene-fb955035

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