| Gene Symbol | ent-gene-1f51bfd1 |
| Transmembrane domain | Residues 31-50 (anchor in outer membrane) |
| Kinase domain | Residues 150-450 (catalytic activity) |
| C-terminal regulatory domain | Residues 451-581 |
| PINK1 autophosphorylation | S228, T313 |
| Ubiquitin phosphorylation | S65 (critical for pathway activation) |
| Parkin phosphorylation | S65 (activates E3 ligase activity) |
| Mitochondrial dysfunction | Reduced mitochondrial membrane potential and ATP production |
| Impaired mitophagy | Failure to clear damaged mitochondria |
| Increased oxidative stress | Accumulation of reactive oxygen species |
| Dopaminergic neuron vulnerability | Specific degeneration of substantia nigra pars compacta neurons |
| Complex I deficiency | Impaired NADH dehydrogenase activity |
| Calcium dysregulation | Altered mitochondrial calcium handling |
| KG Connections | 9 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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