cell 1,215 words KG: ent-gene-1f51bfd1 2026-03-22
kind:cell-typesection:cell-typesstate:published
Contents

PINK1-Deficient Dopamine Neurons

🔬 Protein Info
Gene SymbolPINK1
Full NameDeficient Dopamine Neurons
Chromosome1p36.12
Protein FamilySerine/threonine kinase family
Protein TypeKinase
Functionis a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene [@zheng2021].
Primary ExpressionMitochondrial outer membrane
Molecular Weight63 kDa
PathwaysAmyloid, Apoptosis, Autophagy, Chaperone, Cholesterol
UniProt IDQ9BXM7
NCBI Gene ID65018
Ensembl IDENSG00000158828
OMIM608309
GeneCardsPINK1
Human Protein AtlasPINK1
Associated DiseasesAD, ALI, ALS, APOPTOSIS, Aging
Known Drugs/CompoundsDEFERIPRONE, RAPAMYCIN, MELATONIN, THSG, Gastrodin, icaritin
InteractionsBCL2L13, NLRP3, ABCD3, FIP200, RTN3, SESN2
KG Connections3652 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Mitochondrial Transfer Pathway Enhancement
Score: 0.44
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.41
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.38

Related Analyses (10)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between neurons and glia
neurodegeneration · archived

Related Experiments (9)

s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Selective Vulnerability of Dopaminergic Neurons — Mechanism
validation · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Exercise-BDNF-Mitophagy Biomarker Study in PD
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-1f51bfd1 data_in benchmark_ot_ad_answer_key:PINK1
benchmark_ot_ad_answer_key:PINK1 data_in ent-gene-1f51bfd1