| Gene Symbol | ent-gene-b21b7aa9 |
| Chromosome | 6q23.2 |
| Octopamine | Primarily a peripheral neurotransmitter in invertebrates, octopamine is present at low levels in the mammalian brain where it may modulate norepinephrine signaling through TAAR1. |
| Tryptamine | Another trace amine that activates TAAR1, tryptamine is related to serotonin biosynthesis and may serve as an endogenous hallucinogen ligand. |
| RO5256390 (Ulotaront) | A TAAR1 full agonist with 5-HT2A antagonist properties, developed by Neurocrine Biosciences. It showed promise in schizophrenia clinical trials but did not meet primary endpoints in Phase II studies. |
| SEP-363856 | Another TAAR1 agonist with 5-HT1A partial agonist activity, investigated for schizophrenia and Parkinson's disease psychosis. |
| Eppu (S-THIP) | A TAAR1 antagonist that may have procognitive effects by disinhibiting monoamine signaling. |
| Dopaminergic markers | Many TAAR1 neurons in the VTA and SNc co-express tyrosine hydroxylase (TH) and dopamine transporter (DAT), identifying them as dopaminergic neurons. |
| Serotonergic markers | Raphe TAAR1 neurons often express tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme in serotonin synthesis. |
| Monoamine receptors | TAAR1 shows functional interactions with D2 receptors, 5-HT1A, and 5-HT2A receptors, creating complex signaling integration. |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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