Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about cryptic exon inclusion: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| UNC13A Protein Expression | downregulates | phenotype | 0.85 |
| TDP-43 loss of function | biomarker_for | mechanism | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TDP-43 | inhibits | protein | 0.95 |
| Loss Of Tardbp Function | causes | mechanism | 0.94 |
| HDGFL2 | involved_in | gene | 0.92 |
| TDP-43 | represses | protein | 0.90 |
| TDP-43 loss-of-function | causes | process | 0.90 |
| TDP-43 | targets | protein | 0.80 |
| TARDBP | targets | protein | 0.80 |
| TDP-43 | mediates | protein | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| STMN2 Cryptic Exon Inclusion is the Earliest Loss-of-Functio | 0.721 | ALS | Causal Sequence of TDP-43 Nuclear Cleara |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.664
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.49 · 2026-04-27
closed · Rounds: 4 · Score: 0.50 · 2026-04-13
Hypotheses and analyses mentioning cryptic exon inclusion in their description or question text
No additional research found