Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about epigenetic memory: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Ipsc Differentiation | inhibits | process | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CRISPR-Based Tools | modulates | process | 0.82 |
| Crispr-Based Tools | modulates | mechanism | 0.80 |
| CRISPR-based Tools | modulates | process | 0.80 |
| EZH2 | regulates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Epigenetic Memory Erasure via TET2 Activation | 0.741 | neurodegeneration | Astrocyte reactivity subtypes in neurode |
| Epigenetic Memory Reprogramming for Alzheimer's Disease | 0.611 | neurodegeneration | CRISPR-based therapeutic approaches for |
| Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromat | 0.544 | neurodegeneration | CRISPR-based therapeutic approaches for |
| Epigenetic Memory Engram Therapy for Alzheimer's Disease | 0.455 | spatial-memory | What neural circuits encode and maintain |
| Epigenetic Memory Erasure in Aged Microglia | 0.000 | - | Neuroinflammation and microglial priming |
| Stress-Responsive Epigenetic Memory (SREM) | 0.000 | - | Do different priming stimuli require dis |
Scientific analyses that reference this entity
behavioral neuroscience | 2026-04-11 | 0 hypotheses
immunology | 2026-04-08 | 8 hypotheses Top: 0.380
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Tet2 modulation in Aβ42-injured mouse hippocampal neurons | exploratory | Alzheimer's disease | 0.900 | 0.00 | primary mouse hippocampal neur | proposed | N/A |
| AAV-mediated Tet2 modulation in 2×Tg-AD mice behavioral study | validation | Alzheimer's disease | 0.900 | 0.00 | young APPswe/PSEN1 double-tran | proposed | N/A |
| Acteoside treatment in LPS-induced SALI mouse model | validation | sepsis-associated acute lung i | 0.900 | 0.00 | LPS-induced SALI mouse model | proposed | N/A |
| Tet2 expression analysis in aged 2×Tg-AD mouse brains | exploratory | Alzheimer's disease | 0.850 | 0.00 | APPswe/PSEN1 double-transgenic | proposed | N/A |
| Nrf2 inhibitor ML385 mechanism validation experiment | exploratory | sepsis-associated acute lung i | 0.850 | 0.00 | RAW264.7 cells and/or mouse mo | proposed | N/A |
| Acteoside effects on RAW264.7 macrophage cells | exploratory | sepsis-associated acute lung i | 0.850 | 0.00 | RAW264.7 cells | proposed | N/A |
| Proposed experiment from debate on Epigenetic clocks and biological ag | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | completed | $450,000 |
| CRISPR Gene Correction Approaches for CBS/PSP | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Clonal Hematopoiesis in Nonmalignant Disease: Functional Consequences of Mutated [PMID:40929507] | Koh Y, Tengesdal IW, Jaiswal S | Annu Rev Pathol | 2026 | 1 |
| TET2 guards against unchecked BATF3-induced CAR T cell expansion. [PMID:36755094] | Jain N, Zhao Z, Feucht J, Koche R, Iyer | Nature | 2023 | 1 |
| Clonal Hematopoiesis of Indeterminate Potential: Current Understanding and Futur [PMID:36928826] | Singh I, Singh A | Curr Oncol Rep | 2023 | 1 |
| The function and regulation of TET2 in innate immunity and inflammation. [PMID:33085059] | Cong B, Zhang Q, Cao X | Protein Cell | 2021 | 1 |
| Global epigenomic reconfiguration during mammalian brain development. [PMID:23828890] | Lister R, Mukamel EA, Nery JR, Urich M, | Science | 2013 | 1 |
| TET1 deficiency amplifies macrophage inflammatory signaling associated with Croh [PMID:41896302] | ["Perez R", "Paul R", "Kumar P", "Tutkun | Inflammation research : offici | 2026 | 0 |
| Tet methylcytosine dioxygenase 2(TET2)-dependent epigenetic regulation in the pa [PMID:41811389] | Liu K, Hong Y, Gao Q, Huang J, Liu L, Li | Cellular and molecular life sc | 2026 | 0 |
| Clonal Hematopoiesis in Cardiovascular Risk: Focus on Inflammatory Mechanisms. [PMID:41899316] | ["Sinnadurai S", "Honigberg M", "Meijers | Journal of clinical medicine | 2026 | 0 |
| Clonal Hematopoiesis and Risk of Trastuzumab-Related Cardiotoxic Effects. [PMID:41926089] | Park CS, Ryu G, Ahn HJ, Sun C, Lee SP, K | JAMA oncology | 2026 | 0 |
| Chimeric antigen receptor T-cell therapies related to immune effector cell-assoc [PMID:41914034] | Zhang Y, Yang J, Xin H, Ai K, Yang M, Li | Chinese medical journal | 2026 | 0 |
| Targeting synaptic plasticity and acetylcholine dysregulation in the medial pref [PMID:41014339] | Shi J, Chen M, Zhang Y, Fan X, Wang L et | Psychopharmacology (Berl) | 2026 | 0 |
| Exosome-transmitted microRNA-323a-3p participated in the occurrence of Hirschspr [PMID:41906498] | Shen H, Wang C, Lv X, Gao Z, Qiu Y, Zhi | Epigenomics | 2026 | 0 |
| Molecular Genetic Demonstration of the Evolution of Transformed Mycosis Fungoide [PMID:41873173] | ["Cheng M", "Crisan L", "Zain J", "Afkha | Journal of cutaneous pathology | 2026 | 0 |
| Food-grade TiO2/TDCPP Co-exposure disrupts ACOD1/itaconate axis and is associate [PMID:41796631] | Guo Q, Wang D, Zhao C, Wei S, Hu C, Liu | Food and chemical toxicology : | 2026 | 0 |
| BRAF Mutations in Myeloid Neoplasms: Prevalence, Co-Mutation Landscape, and Clin [PMID:41898318] | ["Mohamed S", "Mohamed A", "Mudarres M", | Biomedicines | 2026 | 0 |
| Huangkui capsule mitigates diabetic nephropathy via epigenetic therapy effects. [PMID:41815912] | ["Yu Y", "Tang H", "Li N", "Ge H", "Wu J | Frontiers in pharmacology | 2026 | 0 |
| Somatic Mutations and Mutation Burden Predict Treatment Response and Survival in [PMID:41922159] | Yang L, Zhang H, Wei Y, Niu H, Liu Y, Zh | American journal of hematology | 2026 | 0 |
| Contribution of rare variation to degenerative orthopedic diseases. [PMID:41859529] | ["Anker-Hansen C", "Manderstedt E", "Lin | Osteoarthritis and cartilage o | 2026 | 0 |
| Expanding the genetic burden of low-evidence genes in pulmonary arterial hyperte [PMID:41882294] | ["Miranda-Alcaraz L", "Mora-G\u00f3mez M | European journal of human gene | 2026 | 0 |
| Azacitidine-induced remission enables allogeneic transplantation in TET2/BCOR-mu [PMID:41924921] | Ortiz CR, Abouzeid H, De Bernardi C, Dur | Haematologica | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.70 · 2026-04-20
closed · Rounds: 4 · Score: 0.93 · 2026-04-10
Hypotheses and analyses mentioning epigenetic memory in their description or question text