gene

EZH2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EZH2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

311Connections

4Hypotheses

8Analyses

50Outgoing

50Incoming

0Experiments

11Debates

Summary

EZH2 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, therapeutic target. Associated with ALS, Als, Bipolar. Connected to 166 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	EZH2
Full Name	Enhancer of Zeste Homolog 2
Chromosome	7q36.1
Function	H3K27me3 is the transcriptionally repressive mark that defines Polycomb-silenced chromatin.
Molecular Weight	85.4 kDa
Amino Acids	746 aa
Exons	20
Pathways	Autophagy, Circadian Rhythm, Epigenetic, Histone Modification, Inflammasome
UniProt ID	Q15910
NCBI Gene ID	2146
Ensembl ID	ENSG00000106462
OMIM	601573
GeneCards	EZH2
Human Protein Atlas	EZH2
Monomethylation (H3K27me1)	Often associated with gene activation
Associated Diseases	Alzheimer disease, Cancer, Infection, Inflammation, major depressive disorder, memory formation
Known Drugs/Compounds	EPZ6438, Tazemetostat
Interactions	AGING, AKT, AMPK, AND, App, ATG16L1
SciDEX Hypotheses	EZH2 Inhibitor Therapy to Restore Neuronal Identit Stress-Responsive Epigenetic Memory (SREM)
KG Connections	311 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EZH2 — AlphaFold Q15910 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

EZH2 — Enhancer of Zeste Homolog 2

gene · 1311 words

→

EZH2 Protein

protein · 621 words

→

Pathway Diagram

graph TD
    EZH2["EZH2"]
    EZH2 -->|"regulates"| TIMP1["TIMP1"]
    EZH2 -->|"regulates"| H3K27me3["H3K27me3"]
    EZH2 -->|"activates"| Als["Als"]
    EZH2 -->|"activates"| Ms["Ms"]
    EZH2 -->|"activates"| Inflammation["Inflammation"]
    EZH2 -.biomarker for.-> Cancer["Cancer"]
    EZH2 -.biomarker for.-> Tumor["Tumor"]
    EZH2 -->|"target for"| Carcinoma["Carcinoma"]
    EPZ6438["EPZ6438"] -->|"inhibits"| EZH2
    STING["STING"] -->|"activates"| EZH2
    GENES["GENES"] -->|"activates"| EZH2
    DNA["DNA"] -->|"activates"| EZH2
    IRF3["IRF3"] -->|"activates"| EZH2
    SOX2["SOX2"] -.biomarker for.-> EZH2
    ATM["ATM"] -.biomarker for.-> EZH2
    GAIN["GAIN"] -.biomarker for.-> EZH2
    BCL_2["BCL-2"] -.biomarker for.-> EZH2

Outgoing (209)

Target	Relation	Type	Str
MMP10	regulates	gene	0.90
H3K27me3	deposits	biomarker	0.90
H3K27me3	catalyzes	mechanism	0.88
Als	regulates	disease	0.85
EBF3	downregulates	unknown	0.85
Cancer	regulates	disease	0.75
Diabetes	activates	disease	0.75
epigenetic regulation	participates_in	pathway	0.75
Carcinoma	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
H3K27ME3	causes	protein	0.70
major depressive disorder	associated_with	disease	0.70
TIMP1	regulates	protein	0.70
H3K27me3 modification	catalyzes	epigenetic_modification	0.70
CANCER	regulates	gene	0.70
H3K27me3	regulates	process	0.70
SYNAPTIC_PLASTICITY	regulates	phenotype	0.70
memory formation	associated_with	phenotype	0.70
AD prefrontal cortex	associated_with	brain_region	0.70
epigenetic memory	regulates	process	0.70
AKT	regulates	gene	0.70
Epigenetic	inhibits	pathway	0.70
synaptic transmission	inhibits	phenotype	0.70
synaptic plasticity	regulates	process	0.70
Alzheimer disease	associated_with	disease	0.70
memory formation	causes	phenotype	0.70
TH	inhibits	gene	0.70
synaptic plasticity genes	inhibits	gene	0.70
autophagy genes	represses	process	0.70
memory formation	essential_for	phenotype	0.70
synaptic plasticity genes	represses	process	0.70
H3K27me3	causes	mechanism	0.70
synaptic plasticity	essential_for	process	0.70
H3K27me3	activates	biomarker	0.70
H3K27me3 at synaptic genes	elevates	mechanism	0.70
H3K27me3 deposition	regulates	mechanism	0.70
synaptic gene silencing	causes	mechanism	0.70
Cancer	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Bipolar	therapeutic_target	disease	0.65
Glioblastoma	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Epilepsy	regulates	disease	0.65
Infection	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
unfolded protein response	participates_in	pathway	0.65

Incoming (102)

Source	Relation	Type	Str
Tazemetostat	inhibits	drug	0.90
PCGF1	upregulates	gene	0.90
BMAL1	interacts_with	gene	0.85
EPZ6438	inhibits	drug	0.70
DNMT1	regulates	gene	0.70
PI3K	regulates	gene	0.70
AKT	inhibits	gene	0.70
TBK1	interacts_with	gene	0.65
NLRP3	regulates	gene	0.60
PPAR	activates	gene	0.60
FOXO3	activates	gene	0.60
TNF	regulates	gene	0.60
BMP2	activates	gene	0.60
AXL	activates	gene	0.60
CD38	inhibits	gene	0.60
KDM6A	inhibits	gene	0.60
PTEN	activates	gene	0.60
TP53	activates	gene	0.60
BMP2	regulates	gene	0.60
STING	activates	gene	0.60
IRF3	activates	gene	0.60
CLOCK	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
CANCER	biomarker_for	gene	0.60
RNA	activates	gene	0.60
CANCER	activates	gene	0.60
AMPK	expressed_in	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
CIRCADIAN RHYTHM	regulates	gene	0.60
TRAF6	inhibits	gene	0.60
SRC	regulates	gene	0.60
ATG16L1	interacts_with	gene	0.60
FOXO1	regulates	gene	0.60
HDAC1	interacts_with	gene	0.60
P53	regulates	gene	0.60
ROS	regulates	gene	0.60
CXCL8	regulates	gene	0.60
TP53	regulates	gene	0.60
GENES	activates	gene	0.60
DNA	activates	gene	0.60
CANCER	inhibits	gene	0.60
INFLAMMATION	activates	gene	0.60
MEK	activates	gene	0.60
SOX2	therapeutic_target	gene	0.60
CDK4	therapeutic_target	gene	0.60
RB1	therapeutic_target	gene	0.60
CDKN2A	therapeutic_target	gene	0.60
PI3K	associated_with	gene	0.60
AKT	associated_with	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
EZH2-Mediated H3K27me3 Spreading in Senescent ALS Microglia	0.714	als	What are the mechanisms by which microgl
Pharmacological EZH2 Inhibition Resets Polycomb-Mediated Rep	0.680	neurodegeneration	epigenetic reprogramming aging neurons
EZH2 Inhibitor Therapy to Restore Neuronal Identity Genes	0.390	neurodegeneration	Comparative epigenetic signatures across
Stress-Responsive Epigenetic Memory (SREM)	0.000	-	Do different priming stimuli require dis

Mentioning Analyses (8)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (11)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning EZH2 in their description or question text

No additional research found

EZH2

Understanding Entity Pages

Summary

Wiki Pages (2)

EZH2 — Enhancer of Zeste Homolog 2

EZH2 Protein

Pathway Diagram

Outgoing (209)

Incoming (102)

Targeting Hypotheses (4)

Mentioning Analyses (8)

What are the mechanisms by which microglial senescence contributes to ALS pathol

Comparative epigenetic signatures: DNA methylation age acceleration and histone

Comparative epigenetic signatures across AD, PD, and ALS

Do different priming stimuli create distinct chromatin landscapes or converge on

Investigate mechanisms of epigenetic reprogramming in aging neurons

Do different priming stimuli require distinct therapeutic approaches or share co

epigenetic reprogramming aging neurons

Epigenetic clocks and biological aging in neurodegeneration

Experiments (0)

Related Papers (0)

Debates (11)

Debate: TBK1 Loss Locks Microglia in an Aged/Senescent Transcriptional State, Fu

Investigate how microglial senescence drives ALS progression through inflammatio

What are the mechanisms by which microglial senescence contributes to ALS pathol

Epigenetic reprogramming of aging neurons represents an active research focus wi

Investigate mechanisms of epigenetic reprogramming in aging neurons [TARGET_ART

Investigate mechanisms of epigenetic reprogramming in aging neurons

The debate presented conflicting evidence for convergent vs. stimulus-specific c

Investigate shared DNA methylation age acceleration and histone modification pat

What are the shared DNA methylation age acceleration and histone modification pa

Do different priming stimuli require distinct therapeutic approaches or share co

Related Research