Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about feedback loop: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| C3aR | associated_with | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| miR-155/Interferon-gamma Feedback Loop as a Reversible Molec | 0.843 | neurodegeneration | How do different microglial subtypes (DA |
| Glucosylceramide Accumulation from GCase Deficiency Disrupts | 0.700 | neurodegeneration | - |
| STING Antagonism Prevents Acute-to-Chronic Neuroinflammation | 0.601 | neuroinflammation | What molecular mechanisms drive the tran |
| A post-trigger CDK5-dominant kinase feedback loop maintains | 0.590 | neurodegeneration | Does tau dendritic missorting persist in |
| Glucosylceramide-mediated feedback loop drives GBA-synuclein | 0.380 | parkinsons | GBA-Synuclein Loop: Therapeutic Strategi |
| Autophagy-Epigenetic Feedback Loop Creates a Compounding Bio | 0.347 | - | Epigenetic clocks as biomarkers for Alzh |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.760
neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.729
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Anti-miR-155 LNA Oligonucleotide Shifts Microglia to Homeostatic State | in_vivo | neurodegeneration | 0.774 | 0.65 | C57BL/6J LPS model (chronic i. | proposed | $58,000 |
| Pain has been frequently reported as an initial symptom and the most t | genetic_association | Parkinson's disease | 0.500 | 0.00 | human | extracted | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Changes in Circulating Levels of miR-30b During Minipuberty and Puberty in Girls [PMID:40899010] | Albrechtsen HM, Saritas G, Winge SB, Mai | J Clin Endocrinol Metab | 2026 | 0 |
| Epigenetics in chronic rhinosinusitis. [PMID:41442742] | Kumar N, Brar T, Lal D | Curr Opin Otolaryngol Head Nec | 2026 | 0 |
| Extracellular vesicles in type 2 diabetes exhibit elevated miR-155 cargo and Ann [PMID:41786286] | Jackson G, Islam H, de Souza Teixeira AA | Life Sci | 2026 | 0 |
| Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207] | Mishra R, Gupta JK | Curr Alzheimer Res | 2026 | 0 |
| Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013] | Gu X, Sun F, Li Y, Yang S, Li Y | Int J Biol Macromol | 2026 | 0 |
| Extracellular Vesicles in Obesity: From Pathophysiological Mediators to Therapeu [PMID:41977323] | Pavlović N, Todorović P, Maglica M, Kopi | Int J Mol Sci | 2026 | 0 |
| Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207] | Mishra R, Gupta JK | Current Alzheimer research | 2026 | 0 |
| Autophagy, aging, and age-related neurodegeneration. [PMID:39406236] | Palmer JE, Wilson N, Son SM | Neuron | 2025 | 0 |
| SMAD3 and PINK1 constitute a new positive feedback loop in regulation of mitopha [PMID:40277323] | Tang M, Lu G, Shen HM | Autophagy | 2025 | 0 |
| Autophagy, aging, and age-related neurodegeneration. [PMID:39406236] | Palmer JE, Wilson N, Son SM, Obrocki P, | Neuron | 2025 | 0 |
| Autophagy-lysosomal-associated neuronal death in neurodegenerative disease. [PMID:39259382] | Nixon Ralph A | Acta neuropathologica | 2024 | 0 |
| Autophagy-lysosomal-associated neuronal death in neurodegenerative disease. [PMID:39259382] | Nixon RA | Acta neuropathologica | 2024 | 0 |
| ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind a [PMID:37127681] | Wang, Wang, Zhang, Hu, Jiang et al. | Archives of toxicology | 2023 | 0 |
| Adaptive Deep Brain Stimulation: From Experimental Evidence Toward Practical Imp [PMID:37148553] | Neumann WJ, Gilron R, Little S | Mov Disord | 2023 | 0 |
| ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind a [PMID:37127681] | Unknown | Archives of toxicology | 2023 | 0 |
| Autophagy in ovary and polycystic ovary syndrome: role, dispute and future persp [PMID:34161185] | Unknown | Autophagy | 2022 | 0 |
| The interplay of ROS and the PI3K/Akt pathway in autophagy regulation. [PMID:33442914] | Kma, Baruah | Biotechnology and applied bioc | 2022 | 0 |
| Autophagy in ovary and polycystic ovary syndrome: role, dispute and future persp [PMID:34161185] | Kumariya, Ubba, Jha, Gayen | Autophagy | 2022 | 0 |
| The interplay of ROS and the PI3K/Akt pathway in autophagy regulation. [PMID:33442914] | Unknown | Biotechnology and applied bioc | 2022 | 0 |
| Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Supports Hepatocellular [PMID:33682185] | Song M, He J, Pan QZ | Hepatology | 2021 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.84 · 2026-04-25
closed · Rounds: 4 · Score: 0.90 · 2026-04-06
Hypotheses and analyses mentioning feedback loop in their description or question text