Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about gut_microbiome: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| SCFA_production | associated_with | pathway | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming | 0.607 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 0 hypotheses
neurodegeneration | 2026-04-01 | 0 hypotheses
neurodegeneration | 2026-04-01 | 0 hypotheses
neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617
neurodegeneration | 2026-04-01 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent au [PMID:35900990] | ["Di Q", "Zhao X", "Tang H", "Li X", "Xi | Autophagy | 2023 | 1 |
| Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861] | ["Han X", "Sun S", "Sun Y", "Song Q", "Z | Autophagy | 2020 | 1 |
| Nlrc4 Inflammasome Expression After Acute Myocardial Infarction in Rats. [PMID:40332346] | Borim PA, Gatto M, Mota GAF, Meirelles A | Int J Mol Sci | 2025 | 0 |
| Berberine Protects Against NLRP3 Inflammasome via Ameliorating Autophagic Impair [PMID:33584302] | Huang S, Liu H, Lin Y, Liu M, Li Y et al | Front Pharmacol | 2020 | 0 |
| Inflammasome and toll-like receptor signaling in human monocytes after successfu [PMID:27260481] | Asmussen A, Fink K, Busch HJ, Helbing T, | Crit Care | 2016 | 0 |
| Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is respon [PMID:24879148] | Guo W, Sun Y, Liu W, Wu X, Guo L et al. | Autophagy | 2014 | 0 |