TLR4 priming is the actionable driver in: How does gut microbiome dysbiosis contribute to neuroinflammation and neurodegeneration th

flowchart TD
    A["Gut Dysbiosis<br/>SCFA-Producing Bacteria Loss"]
    B["Intestinal Permeability<br/>Leaky Gut Endotoxemia"]
    C["LPS Translocation<br/>Portal and Systemic Circulation"]
    D["TLR4 Activation<br/>MD-2 Coreceptor Complex"]
    E["MyD88 Signaling<br/>NF-kappaB and MAPK Cascade"]
    F["Peripheral Cytokine Storm<br/>IL-1beta and TNF Secretion"]
    G["Microglial Priming<br/>Brain Resident Immune Activation"]
    H["Neurodegeneration<br/>Synapse Loss and Tau Pathology"]
    A --> B
    B --> C
    C --> D
    D --> E
    E --> F
    F --> G
    G --> H
    style A fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7
    style D fill:#7b1fa2,stroke:#ce93d8,color:#ce93d8
    style G fill:#b71c1c,stroke:#ef9a9a,color:#ef9a9a
    style H fill:#b71c1c,stroke:#ef9a9a,color:#ef9a9a